GenAge entry for cup-4 (Caenorhabditis elegans)
Gene information (ID: 910)
- Symbol
- cup-4
- Name
- Coelomocyte UPtake defective
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- cup-4 RNAi decreased mean LS by 10% compared to wild type. RNAi of nlp-7 or cup-4 significantly reduces the life span of the eat-2 mutant, a genetic model of dietary restriction, but has no effect on the life span of long-lived mutants resulting from reduced insulin/ IGF-1 signaling or dysfunction of the mitochondrial electron transport chain. The life-span extension observed in wild-type N2 worms by dietary restriction using bacterial dilution is prevented significantly in nlp-7 and cup-4 mutants.
- % change in avg or median lifespan
- Average lifespan is 10% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenDR gene manipulations
- This gene is present as cup-4
Homologs in other organisms
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- View on Entrez Gene database (176104)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar