- Symbol
- inf-1
- Name
- INitiation Factor
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Scaffold protein for translation initiation factors
- Observations
- RNA interference of inf-1 results in an increased lifespan.
- % change in avg or median lifespan
- Mean lifespan is 21.4% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- RNA interference in adulthood resulted in a up to 46% mean lifespan extension.
- % change in avg or median lifespan
- Average lifespan is up to 46% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Post developmental RNAi resulted in a 10% mean lifespan reduction.
- % change in avg or median lifespan
- Average lifespan is 10% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Danio rerio
- eif4a1a
- Danio rerio
- eif4a1b
- Danio rerio
- eif4a2
- Drosophila melanogaster
- eIF-4a
- Homo sapiens
- EIF4A1
- Homo sapiens
- EIF4A2
- Mus musculus
- Eif4a1
- Mus musculus
- Eif4a2
- Rattus norvegicus
- Eif4a2
- Rattus norvegicus
- Eif4a1
- Saccharomyces cerevisiae
- FAL1
- Schizosaccharomyces pombe
- tif1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (175966)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for inf-1 (Caenorhabditis elegans)