Caenorhabditis elegansGenAge entry for daf-18 (Caenorhabditis elegans)

Gene information (ID: 161)

Symbol
daf-18
Name
Abnormal DAuer Formation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Lipid phosphatase

Potential relevance to longevity and/or ageing

Observations
Knockdown of daf-18 decreased lifespan.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    The increased lifespan of daf-2 mutants is partially suppressed in a daf- 2; daf-18 double mutant.
    Lifespan Effect
    Not Recorded
    Genetic Manipulation
    Mutations
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Required for complete dauer formation. Overexpression increases adult lifespan in individual tissues.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        Overexpression resulted in a 30% mean lifespan extension.
        % change in avg or median lifespan
        Average lifespan is 30% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Overexpression
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Drosophila melanogaster is present as Pten
          • A homolog of this gene for Mus musculus is present as Pten
          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as PTEN
          CellAge
          • A homolog of this gene for Homo sapiens is present as PTEN

          Homologs in other organisms

          Danio rerio
          ptena
          Danio rerio
          ptenb
          Drosophila melanogaster
          Pten
          Homo sapiens
          PTEN
          Mus musculus
          Pten
          Rattus norvegicus
          Pten

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (176869)
          Homologues
          Search HomoloGene
          UniProt
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          Internet
          Search Google or Search Google Scholar