Caenorhabditis elegansGenAge entry for dve-1 (Caenorhabditis elegans)

Gene information (ID: 915)

Symbol
dve-1
Name
DVE (Defective proVEntriculus in Drosophila) homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
% change in avg or median lifespan
Average lifespan is 53% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Shortned lifespan compared to wild type controls.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as dve-1

      Homologs in other organisms

      Drosophila melanogaster
      dve

      External links

      WormBase
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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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