Caenorhabditis elegansGenAge entry for egl-8 (Caenorhabditis elegans)

Gene information (ID: 920)

Symbol
egl-8
Name
EGg Laying defective
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Egl-8 mutants showed a 14% mean lifespan reduction (in the daf-16 background ) and a 83% mean lifespan extension (compared to wild type).
% change in avg or median lifespan
Median lifespan is 83% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    15% mean lifespan extension
    % change in avg or median lifespan
    Average lifespan is 15% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      CellAge gene expression
      • A homolog of this gene for Homo sapiens is present as PLCB4

      Homologs in other organisms

      Danio rerio
      PLCB4
      Drosophila melanogaster
      norpA
      Homo sapiens
      PLCB4
      Mus musculus
      Plcb4
      Rattus norvegicus
      Plcb4
      Schizosaccharomyces pombe
      plc1

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (178537)
      Homologues
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      UniProt
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      Internet
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