GenAge entry for inaE (Drosophila melanogaster)
Gene information (ID: 1928)
- Symbol
- inaE
- Name
- inactivation no afterpotential E
- Organism
- Drosophila melanogaster (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Fly mutants (EP-element insertion), exhibiting up-regulation of DAGL, display extended lifespan (mean is 72% higher) and enhanced oxidative stress response. Complementarily, mutants exhibiting down-regulation of DAGL have a shortened lifespan (mean is 50% lower) and reduced oxidative stress resistance. Additionally, transgenic overexpression of DAGL results in increased mean lifespan (up to 41%).
- % change in avg or median lifespan
- Mean lifespan is 73% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- View on Entrez Gene database (32343)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar