Drosophila melanogasterGenAge entry for dm (Drosophila melanogaster)

Gene information (ID: 1955)

Symbol
dm
Name
diminutive
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of dm (ortholog of the mammalian Myc) during larval development increases the frequency and the severity of somatic mutations, and shortens median lifespan by 42-47%. Maximum lifespan is 30-40% shorter. Contrastly, dm haploinsufficiency lowers the frequency of somatic mutations and extends lifespan by about 14%.
% change in max lifespan
Maximum lifespan is up to 40% lower.
% change in avg or median lifespan
Median lifespan is up to 47% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Myc
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as MYC
    CellAge
    • A homolog of this gene for Homo sapiens is present as MYC

    Homologs in other organisms

    Danio rerio
    mycb
    Danio rerio
    mycla
    Danio rerio
    mych
    Danio rerio
    myclb
    Danio rerio
    mycn
    Danio rerio
    myca
    Homo sapiens
    MYCN
    Homo sapiens
    MYC
    Homo sapiens
    MYCL
    Mus musculus
    Bmyc
    Mus musculus
    Mycn
    Mus musculus
    Mycl
    Mus musculus
    Myc
    Mus musculus
    Mycs
    Rattus norvegicus
    Mycn
    Rattus norvegicus
    Bmyc
    Rattus norvegicus
    Myc
    Rattus norvegicus
    Mycs
    Rattus norvegicus
    Mycl

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (31310)
    Homologues
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    UniProt
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    Internet
    Search Google or Search Google Scholar