GenAge entry for let-23 (Caenorhabditis elegans)
Gene information (ID: 953)
- Symbol
- let-23
- Name
- LEThal
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Let-23 mutants (reduction-of-function) survive less robustly in middle adulthood than matched wild type controls (19% decrease of median lifespan, 8% decrease of maximum lifespan)
- % change in max lifespan
- Maximum lifespan is 8% higher.
- % change in avg or median lifespan
- Median lifespan is 19% higher.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Let-23 mutants (gain-of-function) survive more robustly in middle adulthood (29% increase of median lifespan, 9% increase of maximum lifespan.
- % change in max lifespan
- Maximum lifespan is 9% higher.
- % change in avg or median lifespan
- Median lifespan is 29% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- View on Entrez Gene database (174462)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar