Caenorhabditis elegansGenAge entry for egl-3 (Caenorhabditis elegans)

Gene information (ID: 212)

Symbol
egl-3
Name
EGg Laying defective
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Homolog of a mammalian proprotein convertase that participates in peptide secretion

Potential relevance to longevity and/or ageing

Observations
RNA interference results in life-extension.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    29% (daf-16 mutant) mean lifespan reduction and 65% (wt) mean lifespan extension.
    % change in avg or median lifespan
    Average lifespan is 65% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as KEX2

      Homologs in other organisms

      Danio rerio
      pcsk2
      Drosophila melanogaster
      amon
      Homo sapiens
      PCSK2
      Mus musculus
      Pcsk2
      Rattus norvegicus
      Pcsk2
      Saccharomyces cerevisiae
      KEX2
      Schizosaccharomyces pombe
      krp1

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (179412)
      Homologues
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      UniProt
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      Internet
      Search Google or Search Google Scholar