- Symbol
- egl-3
- Name
- EGg Laying defective
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Homolog of a mammalian proprotein convertase that participates in peptide secretion
- Observations
- RNA interference results in life-extension.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- 29% (daf-16 mutant) mean lifespan reduction and 65% (wt) mean lifespan extension.
- % change in avg or median lifespan
- Average lifespan is 65% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as KEX2
- Danio rerio
- pcsk2
- Drosophila melanogaster
- amon
- Homo sapiens
- PCSK2
- Mus musculus
- Pcsk2
- Rattus norvegicus
- Pcsk2
- Saccharomyces cerevisiae
- KEX2
- Schizosaccharomyces pombe
- krp1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (179412)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar