The Pawr gene and its possible relation to ageing in mice

Gene information (ID: 496)

Symbol: Pawr
Aliases: PAR4; Par-4; 2310001G03Rik
Name: PRKC, apoptosis, WT1, regulator
Organism: Mus musculus (AnAge)
Known functions and activities: Tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal/immortalized cells

Potential relevance to longevity and/or ageing

Observations

Par4-null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4-null mice were particularly sensitive to the development of proliferative lesions. Most (80%) Par4-null females presented endometrial hyperplasia by 9 months of age, and a significant proportion (36%) developed endometrial adenocarcinomas after 1 year of age. Similarly, Par4- null males showed a high incidence of prostate hyperplasia and prostatic intraepithelial neoplasias, and were extraordinarily sensitive to testosterone-induced prostate hyperplasia. 25% reduction in mean LS was observed compared to WT and 20% reduction in MLS. Heterozygote KOLS did not differ significantly from the WT.

% change in max lifespan

Maximum lifespan is 20% lower.

% change in avg or median lifespan

Average lifespan is 25% lower.

Lifespan Effect

Decrease

Genetic Manipulation

Deletion

Longevity Category

Pro-Longevity

Primary reference

Observations

Mice overexpressing the pro-apoptotic protein domain were resistant to tumours. Transgenic animals showed normal fertility, viability, and ageing, though they were slightly longer-lived possibly because of the cancer-resistance.

Lifespan Effect

Increase

Genetic Manipulation

Overexpression