Caenorhabditis elegansGenAge entry for ceh-37 (Caenorhabditis elegans)

Gene information (ID: 1825)

Symbol
ceh-37
Name
Protein CEH-37
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
% change in avg or median lifespan
Average lifespan is 8% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    CellAge
    • A homolog of this gene for Homo sapiens is present as OTX2

    Homologs in other organisms

    Danio rerio
    otx1b
    Danio rerio
    otx2
    Danio rerio
    crx
    Danio rerio
    otx5
    Danio rerio
    otx1a
    Drosophila melanogaster
    oc
    Homo sapiens
    OTX2
    Homo sapiens
    OTX1
    Homo sapiens
    CRX
    Mus musculus
    Otx2
    Mus musculus
    Crx
    Mus musculus
    Otx1
    Rattus norvegicus
    Otx2
    Rattus norvegicus
    LOC100911492
    Rattus norvegicus
    Otx1
    Rattus norvegicus
    Crx

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (181530)
    Homologues
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    UniProt
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    Internet
    Search Google or Search Google Scholar