Caenorhabditis elegansGenAge entry for smk-1 (Caenorhabditis elegans)

Gene information (ID: 616)

Symbol
smk-1
Name
suppressor of MEK null
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Stress response

Potential relevance to longevity and/or ageing

Observations
RNA interference of smk-1 completely suppressed the extended longevity of daf-2 mutations and partly the life-extension of clk-1 mutants. It only slightly shortened the lifespan of wild-type worms.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNAi led to a 44% decrease in median lifespan in daf-2 background and 21% decrease in lifespan in wild-type background.
    % change in avg or median lifespan
    Lifespan is 21% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenDR gene manipulations
      • This gene is present as smk-1

      Homologs in other organisms

      Danio rerio
      smek1
      Danio rerio
      PPP4R3B
      Drosophila melanogaster
      flfl
      Homo sapiens
      PPP4R3CP
      Homo sapiens
      PPP4R3B
      Homo sapiens
      PPP4R3A
      Mus musculus
      4930415L06Rik
      Mus musculus
      4932429P05Rik
      Mus musculus
      Ppp4r3b
      Mus musculus
      Ppp4r3a
      Rattus norvegicus
      Ppp4r3b
      Rattus norvegicus
      Ppp4r3a
      Rattus norvegicus
      Ppp4r3c
      Saccharomyces cerevisiae
      PSY2
      Schizosaccharomyces pombe
      SPBC216.01c

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (179243)
      Homologues
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      UniProt
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      Internet
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