GenAge Human Genes: List of Entries

Last update: April 19, 2014

HGNC Symbol HAGRID Common name Function(s) References Interactions
A2M 139 alpha-2-macroglobulin 5 3
ABL1 78 c-abl oncogene 1, receptor tyrosine kinase 5 7
ADCY5 255 adenylate cyclase 5 1 1
AGPAT2 187 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) 3 0
AGTR1 264 angiotensin II receptor, type 1 5 1
AIFM1 135 apoptosis-inducing factor, mitochondrion-associated, 1 4 1
AKT1 35 v-akt murine thymoma viral oncogene homolog 1 45 12
APEX1 195 APEX nuclease (multifunctional DNA repair enzyme) 1 11 8
APOC3 102 apolipoprotein C-III 7 0
APOE 138 apolipoprotein E 28 3
APP 137 amyloid beta (A4) precursor protein 35 3
APTX 95 aprataxin 6 3
AR 110 androgen receptor 8 20
ARHGAP1 249 Rho GTPase activating protein 1 1 1
ARNTL 251 aryl hydrocarbon receptor nuclear translocator-like 11 3
ATF2 193 activating transcription factor 2 10 10
ATM 9 ataxia telangiectasia mutated 42 12
ATP5O 146 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 3 0
ATR 231 ataxia telangiectasia and Rad3 related 7 4
BAK1 278 BCL2-antagonist/killer 1 3 4
BAX 119 BCL2-associated X protein 21 3
BCL2 69 B-cell CLL/lymphoma 2 30 7
BDNF 191 brain-derived neurotrophic factor 27 1
BLM 68 Bloom syndrome, RecQ helicase-like 15 8
BMI1 188 BMI1 polycomb ring finger oncogene 13 0
BRCA1 61 breast cancer 1, early onset 21 27
BRCA2 79 breast cancer 2, early onset 8 4
BSCL2 186 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 3 0
BUB1B 197 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 10 3
BUB3 240 budding uninhibited by benzimidazoles 3 homolog (yeast) 4 1
C1QA 287 complement component 1, q subcomponent, A chain 1 0
CACNA1A 133 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 7 0
CAT 107 catalase 37 1
CCNA2 177 cyclin A2 3 7
CDC42 250 cell division cycle 42 (GTP binding protein, 25kDa) 2 3
CDK1 201 cyclin-dependent kinase 1 4 5
CDK7 299 cyclin-dependent kinase 7 0 0
CDKN1A 284 cyclin-dependent kinase inhibitor 1A (p21, Cip1) 7 3
CDKN2A 226 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 35 1
CDKN2B 288 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2 0
CEBPA 88 CCAAT/enhancer binding protein (C/EBP), alpha 14 7
CEBPB 89 CCAAT/enhancer binding protein (C/EBP), beta 9 16
CETP 262 cholesteryl ester transfer protein, plasma 7 0
CHEK2 247 CHK2 checkpoint homolog (S. pombe) 8 6
CISD2 265 CDGSH iron sulfur domain 2 2 0
CLOCK 252 clock homolog (mouse) 17 1
CLU 220 clusterin 16 6
CNR1 282 cannabinoid receptor 1 (brain) 4 0
COQ7 132 coenzyme Q7 homolog, ubiquinone (yeast) 11 0
CREB1 192 cAMP responsive element binding protein 1 15 5
CREBBP 64 CREB binding protein 11 19
CSNK1E 244 casein kinase 1, epsilon 7 0
CTGF 206 connective tissue growth factor 3 2
CTNNB1 223 catenin (cadherin-associated protein), beta 1, 88kDa 16 9
DBN1 228 drebrin 1 4 0
DDIT3 203 DNA-damage-inducible transcript 3 4 4
DGAT1 291 diacylglycerol O-acyltransferase 1 0 0
DLL3 225 delta-like 3 (Drosophila) 12 0
E2F1 18 E2F transcription factor 1 14 8
EEF1A1 189 eukaryotic translation elongation factor 1 alpha 1 5 0
EEF1E1 266 eukaryotic translation elongation factor 1 epsilon 1 3 0
EEF2 103 eukaryotic translation elongation factor 2 5 1
EFEMP1 260 EGF-containing fibulin-like extracellular matrix protein 1 3 0
EGF 48 epidermal growth factor (beta-urogastrone) 15 6
EGFR 40 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 13 16
EGR1 76 early growth response 1 5 4
EIF5A2 289 eukaryotic translation initiation factor 5A2 0 0
ELN 230 elastin 9 0
EMD 121 emerin 4 1
EP300 94 E1A binding protein p300 11 20
EPOR 52 erythropoietin receptor 5 6
EPS8 267 epidermal growth factor receptor pathway substrate 8 5 1
ERBB2 41 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 9 10
ERCC1 149 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) 13 2
ERCC2 11 excision repair cross-complementing rodent repair deficiency, complementation group 2 19 5
ERCC3 104 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) 10 4
ERCC4 261 excision repair cross-complementing rodent repair deficiency, complementation group 4 7 2
ERCC5 109 excision repair cross-complementing rodent repair deficiency, complementation group 5 5 4
ERCC6 92 excision repair cross-complementing rodent repair deficiency, complementation group 6 16 5
ERCC8 12 excision repair cross-complementing rodent repair deficiency, complementation group 8 10 2
ESR1 216 estrogen receptor 1 23 15
FAS 115 Fas (TNF receptor superfamily, member 6) 26 1
FEN1 114 flap structure-specific endonuclease 1 10 4
FGF21 293 fibroblast growth factor 21 0 0
FGF23 259 fibroblast growth factor 23 8 0
FGFR1 169 fibroblast growth factor receptor 1 8 2
FLT1 171 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 3 3
FOS 50 FBJ murine osteosarcoma viral oncogene homolog 19 9
FOXM1 131 forkhead box M1 21 1
FOXO1 124 forkhead box O1 43 6
FOXO3 123 forkhead box O3 56 2
FOXO4 183 forkhead box O4 19 3
GCLC 237 glutamate-cysteine ligase, catalytic subunit 7 1
GCLM 238 glutamate-cysteine ligase, modifier subunit 6 1
GH1 26 growth hormone 1 66 1
GHR 1 growth hormone receptor 32 12
GHRH 2 growth hormone releasing hormone 14 3
GHRHR 222 growth hormone releasing hormone receptor 16 1
GPX1 153 glutathione peroxidase 1 27 1
GPX4 257 glutathione peroxidase 4 (phospholipid hydroperoxidase) 2 0
GRB2 122 growth factor receptor-bound protein 2 7 23
GRN 300 granulin 0 0
GSK3A 295 glycogen synthase kinase 3 alpha 0 0
GSK3B 97 glycogen synthase kinase 3 beta 7 3
GSR 154 glutathione reductase 12 0
GSS 155 glutathione synthetase 6 0
GSTA4 156 glutathione S-transferase alpha 4 8 0
GSTP1 157 glutathione S-transferase pi 1 13 1
GTF2H2 111 general transcription factor IIH, polypeptide 2, 44kDa 3 3
H2AFX 212 H2A histone family, member X 12 4
HBP1 196 HMG-box transcription factor 1 5 4
HDAC1 151 histone deacetylase 1 11 19
HDAC2 207 histone deacetylase 2 7 7
HDAC3 25 histone deacetylase 3 7 7
HELLS 101 helicase, lymphoid-specific 6 0
HESX1 184 HESX homeobox 1 4 2
HIC1 253 hypermethylated in cancer 1 2 1
HIF1A 65 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 17 6
HMGB1 176 high-mobility group box 1 9 12
HMGB2 178 high-mobility group box 2 5 3
HOXB7 213 homeobox B7 5 2
HOXC4 214 homeobox C4 4 2
HRAS 38 v-Ha-ras Harvey rat sarcoma viral oncogene homolog 21 7
HSF1 125 heat shock transcription factor 1 23 10
HSP90AA1 74 heat shock protein 90kDa alpha (cytosolic), class A member 1 10 15
HSPA1A 160 heat shock 70kDa protein 1A 31 10
HSPA1B 161 heat shock 70kDa protein 1B 4 0
HSPA8 199 heat shock 70kDa protein 8 12 5
HSPA9 152 heat shock 70kDa protein 9 (mortalin) 4 1
HSPD1 159 heat shock 60kDa protein 1 (chaperonin) 6 2
HTRA2 294 HtrA serine peptidase 2 0 0
HTT 98 huntingtin 17 6
IGF1 28 insulin-like growth factor 1 (somatomedin C) 118 2
IGF1R 15 insulin-like growth factor 1 receptor 36 12
IGF2 29 insulin-like growth factor 2 (somatomedin A) 21 2
IGFBP2 279 insulin-like growth factor binding protein 2, 36kDa 1 0
IGFBP3 73 insulin-like growth factor binding protein 3 10 2
IKBKB 297 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0 0
IL2 46 interleukin 2 7 2
IL2RG 49 interleukin 2 receptor, gamma (severe combined immunodeficiency) 2 4
IL6 144 interleukin 6 (interferon, beta 2) 23 2
IL7 167 interleukin 7 6 2
IL7R 27 interleukin 7 receptor 5 6
INS 30 insulin 77 5
INSR 42 insulin receptor 33 11
IRS1 32 insulin receptor substrate 1 21 9
IRS2 34 insulin receptor substrate 2 16 10
JAK2 215 Janus kinase 2 9 13
JUN 172 jun oncogene 22 22
JUND 45 jun D proto-oncogene 7 7
KCNA3 268 potassium voltage-gated channel, shaker-related subfamily, member 3 6 1
KL 17 klotho 33 0
LEP 217 leptin 36 3
LEPR 218 leptin receptor 14 4
LMNA 14 lamin A/C 61 4
LMNB1 181 lamin B1 5 3
LRP2 134 low density lipoprotein receptor-related protein 2 2 4
MAP3K5 179 mitogen-activated protein kinase kinase kinase 5 4 5
MAPK14 168 mitogen-activated protein kinase 14 28 6
MAPK3 175 mitogen-activated protein kinase 3 12 4
MAPK8 163 mitogen-activated protein kinase 8 26 11
MAPK9 174 mitogen-activated protein kinase 9 16 6
MAPT 205 microtubule-associated protein tau 35 5
MAX 208 MYC associated factor X 5 4
MDM2 210 Mdm2 p53 binding protein homolog (mouse) 9 11
MED1 173 mediator complex subunit 1 2 5
MIF 290 macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0 0
MLH1 243 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 5 3
MSRA 127 methionine sulfoxide reductase A 11 0
MT-CO1 158 mitochondrially encoded cytochrome c oxidase I 5 0
MT1E 292 metallothionein 1E 0 0
MTOR 221 mechanistic target of rapamycin (serine/threonine kinase) 26 0
MXD1 209 MAX dimerization protein 1 2 5
MXI1 90 MAX interactor 1 3 2
MYC 39 v-myc myelocytomatosis viral oncogene homolog (avian) 22 12
NBN 44 nibrin 22 8
NCOR1 43 nuclear receptor co-repressor 1 6 9
NCOR2 276 nuclear receptor corepressor 2 1 8
NFE2L2 283 nuclear factor (erythroid-derived 2)-like 2 7 2
NFKB1 82 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 25 11
NFKB2 20 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 24 3
NFKBIA 219 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 9 5
NGF 31 nerve growth factor (beta polypeptide) 13 2
NGFR 37 nerve growth factor receptor (TNFR superfamily, member 16) 5 2
NOG 229 noggin 7 0
NR3C1 75 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 14 23
NRG1 24 neuregulin 1 6 3
NUDT1 296 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0 0
PAPPA 254 pregnancy-associated plasma protein A, pappalysin 1 8 0
PARP1 60 poly (ADP-ribose) polymerase 1 39 7
PCK1 248 phosphoenolpyruvate carboxykinase 1 (soluble) 2 0
PCMT1 162 protein-L-isoaspartate (D-aspartate) O-methyltransferase 5 0
PCNA 113 proliferating cell nuclear antigen 12 19
PDGFB 47 platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 7 3
PDGFRA 285 platelet-derived growth factor receptor, alpha polypeptide 4 3
PDGFRB 51 platelet-derived growth factor receptor, beta polypeptide 4 7
PDPK1 87 3-phosphoinositide dependent protein kinase-1 4 3
PEX5 58 peroxisomal biogenesis factor 5 4 2
PIK3CA 286 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1 1
PIK3CB 36 phosphoinositide-3-kinase, catalytic, beta polypeptide 22 2
PIK3R1 185 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 16 13
PIN1 62 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 9 3
PLAU 10 plasminogen activator, urokinase 9 1
PLCG2 57 phospholipase C, gamma 2 (phosphatidylinositol-specific) 6 2
PMCH 242 pro-melanin-concentrating hormone 6 0
PML 96 promyelocytic leukemia 11 13
POLA1 204 polymerase (DNA directed), alpha 1, catalytic subunit 9 3
POLB 236 polymerase (DNA directed), beta 14 3
POLD1 118 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 11 2
POLG 72 polymerase (DNA directed), gamma 11 0
PON1 142 paraoxonase 1 10 1
POU1F1 4 POU class 1 homeobox 1 20 4
PPARA 55 peroxisome proliferator-activated receptor alpha 13 7
PPARG 263 peroxisome proliferator-activated receptor gamma 8 2
PPARGC1A 256 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 15 4
PPM1D 246 protein phosphatase, Mg2+/Mn2+ dependent, 1D 1 0
PPP1CA 227 protein phosphatase 1, catalytic subunit, alpha isozyme 3 2
PRDX1 141 peroxiredoxin 1 4 0
PRKCA 99 protein kinase C, alpha 4 12
PRKCD 54 protein kinase C, delta 4 7
PRKDC 106 protein kinase, DNA-activated, catalytic polypeptide 16 12
PROP1 5 PROP paired-like homeobox 1 29 2
PSEN1 224 presenilin 1 18 4
PTEN 63 phosphatase and tensin homolog 16 3
PTGS2 198 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 11 1
PTK2 166 PTK2 protein tyrosine kinase 2 5 7
PTK2B 165 PTK2B protein tyrosine kinase 2 beta 2 7
PTPN1 33 protein tyrosine phosphatase, non-receptor type 1 5 6
PTPN11 19 protein tyrosine phosphatase, non-receptor type 11 7 10
PYCR1 280 pyrroline-5-carboxylate reductase 1 1 0
RAD51 84 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 10 6
RAD52 147 RAD52 homolog (S. cerevisiae) 3 3
RAE1 241 RAE1 RNA export 1 homolog (S. pombe) 2 0
RB1 120 retinoblastoma 1 46 20
RECQL4 128 RecQ protein-like 4 11 0
RELA 143 v-rel reticuloendotheliosis viral oncogene homolog A (avian) 32 22
RET 56 ret proto-oncogene 4 3
RGN 145 regucalcin (senescence marker protein-30) 6 0
RPA1 67 replication protein A1, 70kDa 5 5
S100B 70 S100 calcium binding protein B 7 2
SDHC 182 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 5 0
SHC1 3 SHC (Src homology 2 domain containing) transforming protein 1 29 28
SIN3A 200 SIN3 homolog A, transcription regulator (yeast) 3 6
SIRT1 150 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) 82 1
SIRT3 275 sirtuin 3 4 0
SIRT6 239 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) 15 0
SIRT7 269 sirtuin 7 3 0
SLC13A1 270 solute carrier family 13 (sodium/sulfate symporters), member 1 3 0
SNCG 140 synuclein, gamma (breast cancer-specific protein 1) 5 3
SOCS2 271 suppressor of cytokine signaling 2 7 3
SOD1 130 superoxide dismutase 1, soluble 45 1
SOD2 129 superoxide dismutase 2, mitochondrial 55 0
SP1 170 Sp1 transcription factor 13 13
SQSTM1 298 sequestosome 1 0 0
SST 53 somatostatin 8 2
SSTR3 100 somatostatin receptor 3 2 2
STAT3 22 signal transducer and activator of transcription 3 (acute-phase response factor) 13 15
STAT5A 23 signal transducer and activator of transcription 5A 5 13
STAT5B 21 signal transducer and activator of transcription 5B 5 6
STK11 93 serine/threonine kinase 11 5 2
STUB1 245 STIP1 homology and U-box containing protein 1 1 5
SUMO1 211 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 6 15
SUN1 277 Sad1 and UNC84 domain containing 1 1 0
TAF1 180 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 1 9
TBP 194 TATA box binding protein 6 11
TCF3 59 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 7 2
TERC 7 telomerase RNA component 34 2
TERF1 105 telomeric repeat binding factor (NIMA-interacting) 1 9 2
TERF2 116 telomeric repeat binding factor 2 18 3
TERT 8 telomerase reverse transcriptase 62 6
TFAP2A 190 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 7 2
TFDP1 202 transcription factor Dp-1 4 4
TGFB1 91 transforming growth factor, beta 1 25 2
TNF 86 tumor necrosis factor (TNF superfamily, member 2) 20 5
TOP1 83 topoisomerase (DNA) I 9 5
TOP2A 80 topoisomerase (DNA) II alpha 170kDa 8 6
TOP2B 81 topoisomerase (DNA) II beta 180kDa 8 4
TOP3B 148 topoisomerase (DNA) III beta 7 0
TP53 6 tumor protein p53 139 62
TP53BP1 274 tumor protein p53 binding protein 1 7 6
TP63 234 tumor protein p63 9 1
TP73 281 tumor protein p73 3 9
TPP2 273 tripeptidyl peptidase II 2 0
TXN 16 thioredoxin 15 3
UBB 66 ubiquitin B 8 1
UBE2I 85 ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 5 10
UCHL1 136 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 6 1
UCP1 258 uncoupling protein 1 (mitochondrial, proton carrier) 5 0
UCP2 235 uncoupling protein 2 (mitochondrial, proton carrier) 22 1
UCP3 232 uncoupling protein 3 (mitochondrial, proton carrier) 22 1
VCP 71 valosin-containing protein 3 4
VEGFA 77 vascular endothelial growth factor A 15 2
WRN 13 Werner syndrome, RecQ helicase-like 88 20
XPA 126 xeroderma pigmentosum, complementation group A 15 3
XRCC5 112 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 24 6
XRCC6 117 X-ray repair complementing defective repair in Chinese hamster cells 6 19 12
YWHAZ 164 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 3 13
ZMPSTE24 233 zinc metallopeptidase (STE24 homolog, S. cerevisiae) 13 0

Entry selected based on evidence directly linking the gene product to ageing in humans
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Entry selected based on evidence linking the gene or its product to human longevity and/or multiple age-related phenotypes
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing or showing the gene product to be an effector of genes related to ageing