GenAge Human Genes: List of Entries

Last update: September 19, 2012

HGNC Symbol HAGRID Common name Function(s) References Interactions
A2M 0139 alpha-2-macroglobulin 5 3
ABL1 0078 c-abl oncogene 1, receptor tyrosine kinase 5 7
ADCY5 0255 adenylate cyclase 5 1 1
AGPAT2 0187 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) 3 0
AGTR1 0264 angiotensin II receptor, type 1 5 1
AIFM1 0135 apoptosis-inducing factor, mitochondrion-associated, 1 4 1
AKT1 0035 v-akt murine thymoma viral oncogene homolog 1 45 12
APEX1 0195 APEX nuclease (multifunctional DNA repair enzyme) 1 11 8
APOC3 0102 apolipoprotein C-III 7 0
APOE 0138 apolipoprotein E 28 3
APP 0137 amyloid beta (A4) precursor protein 35 3
APTX 0095 aprataxin 6 3
AR 0110 androgen receptor 8 20
ARHGAP1 0249 Rho GTPase activating protein 1 1 1
ARNTL 0251 aryl hydrocarbon receptor nuclear translocator-like 11 3
ATF2 0193 activating transcription factor 2 10 10
ATM 0009 ataxia telangiectasia mutated 42 13
ATP5O 0146 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 3 0
ATR 0231 ataxia telangiectasia and Rad3 related 7 4
BAK1 0278 BCL2-antagonist/killer 1 3 4
BAX 0119 BCL2-associated X protein 21 3
BCL2 0069 B-cell CLL/lymphoma 2 30 7
BDNF 0191 brain-derived neurotrophic factor 27 1
BLM 0068 Bloom syndrome, RecQ helicase-like 15 9
BMI1 0188 BMI1 polycomb ring finger oncogene 13 0
BRCA1 0061 breast cancer 1, early onset 21 28
BRCA2 0079 breast cancer 2, early onset 8 4
BSCL2 0186 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 3 0
BUB1B 0197 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 10 3
BUB3 0240 budding uninhibited by benzimidazoles 3 homolog (yeast) 4 1
C1QA 0287 complement component 1, q subcomponent, A chain 1 0
CACNA1A 0133 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 7 0
CAT 0107 catalase 37 1
CCNA2 0177 cyclin A2 3 7
CDC42 0250 cell division cycle 42 (GTP binding protein, 25kDa) 2 3
CDK1 0201 cyclin-dependent kinase 1 4 5
CDKN1A 0284 cyclin-dependent kinase inhibitor 1A (p21, Cip1) 7 3
CDKN2A 0226 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 35 1
CDKN2B 0288 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2 0
CEBPA 0088 CCAAT/enhancer binding protein (C/EBP), alpha 14 7
CEBPB 0089 CCAAT/enhancer binding protein (C/EBP), beta 9 16
CETP 0262 cholesteryl ester transfer protein, plasma 7 0
CHEK2 0247 CHK2 checkpoint homolog (S. pombe) 8 6
CISD2 0265 CDGSH iron sulfur domain 2 2 0
CLOCK 0252 clock homolog (mouse) 17 1
CLU 0220 clusterin 16 6
CNR1 0282 cannabinoid receptor 1 (brain) 4 0
COQ7 0132 coenzyme Q7 homolog, ubiquinone (yeast) 11 0
CREB1 0192 cAMP responsive element binding protein 1 15 5
CREBBP 0064 CREB binding protein 11 19
CSNK1E 0244 casein kinase 1, epsilon 7 0
CTGF 0206 connective tissue growth factor 3 2
CTNNB1 0223 catenin (cadherin-associated protein), beta 1, 88kDa 16 9
DBN1 0228 drebrin 1 4 0
DDIT3 0203 DNA-damage-inducible transcript 3 4 4
DLL3 0225 delta-like 3 (Drosophila) 12 0
E2F1 0018 E2F transcription factor 1 14 8
EEF1A1 0189 eukaryotic translation elongation factor 1 alpha 1 5 0
EEF1E1 0266 eukaryotic translation elongation factor 1 epsilon 1 3 0
EEF2 0103 eukaryotic translation elongation factor 2 5 1
EFEMP1 0260 EGF-containing fibulin-like extracellular matrix protein 1 3 0
EGF 0048 epidermal growth factor (beta-urogastrone) 15 6
EGFR 0040 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 13 16
EGR1 0076 early growth response 1 5 4
ELN 0230 elastin 9 0
EMD 0121 emerin 4 1
EP300 0094 E1A binding protein p300 11 20
EPOR 0052 erythropoietin receptor 5 6
EPS8 0267 epidermal growth factor receptor pathway substrate 8 5 1
ERBB2 0041 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 9 10
ERCC1 0149 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) 13 2
ERCC2 0011 excision repair cross-complementing rodent repair deficiency, complementation group 2 19 5
ERCC3 0104 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) 10 4
ERCC4 0261 excision repair cross-complementing rodent repair deficiency, complementation group 4 7 2
ERCC5 0109 excision repair cross-complementing rodent repair deficiency, complementation group 5 5 4
ERCC6 0092 excision repair cross-complementing rodent repair deficiency, complementation group 6 16 5
ERCC8 0012 excision repair cross-complementing rodent repair deficiency, complementation group 8 10 2
ESR1 0216 estrogen receptor 1 23 15
FAS 0115 Fas (TNF receptor superfamily, member 6) 26 1
FEN1 0114 flap structure-specific endonuclease 1 10 4
FGF23 0259 fibroblast growth factor 23 8 0
FGFR1 0169 fibroblast growth factor receptor 1 8 2
FLT1 0171 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 3 3
FOS 0050 FBJ murine osteosarcoma viral oncogene homolog 19 9
FOXM1 0131 forkhead box M1 21 1
FOXO1 0124 forkhead box O1 43 6
FOXO3 0123 forkhead box O3 56 2
FOXO4 0183 forkhead box O4 19 3
GCLC 0237 glutamate-cysteine ligase, catalytic subunit 7 1
GCLM 0238 glutamate-cysteine ligase, modifier subunit 6 1
GH1 0026 growth hormone 1 66 1
GHR 0001 growth hormone receptor 32 12
GHRH 0002 growth hormone releasing hormone 14 3
GHRHR 0222 growth hormone releasing hormone receptor 16 1
GPX1 0153 glutathione peroxidase 1 27 1
GPX4 0257 glutathione peroxidase 4 (phospholipid hydroperoxidase) 2 0
GRB2 0122 growth factor receptor-bound protein 2 7 23
GSK3B 0097 glycogen synthase kinase 3 beta 7 3
GSR 0154 glutathione reductase 12 0
GSS 0155 glutathione synthetase 6 0
GSTA4 0156 glutathione S-transferase alpha 4 8 0
GSTP1 0157 glutathione S-transferase pi 1 13 1
GTF2H2 0111 general transcription factor IIH, polypeptide 2, 44kDa 3 3
H2AFX 0212 H2A histone family, member X 12 4
HBP1 0196 HMG-box transcription factor 1 5 4
HDAC1 0151 histone deacetylase 1 11 20
HDAC2 0207 histone deacetylase 2 7 7
HDAC3 0025 histone deacetylase 3 7 7
HELLS 0101 helicase, lymphoid-specific 6 0
HESX1 0184 HESX homeobox 1 4 2
HIC1 0253 hypermethylated in cancer 1 2 1
HIF1A 0065 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 17 6
HMGB1 0176 high-mobility group box 1 9 12
HMGB2 0178 high-mobility group box 2 5 3
HOXB7 0213 homeobox B7 5 2
HOXC4 0214 homeobox C4 4 2
HRAS 0038 v-Ha-ras Harvey rat sarcoma viral oncogene homolog 21 7
HSF1 0125 heat shock transcription factor 1 23 10
HSP90AA1 0074 heat shock protein 90kDa alpha (cytosolic), class A member 1 10 15
HSPA1A 0160 heat shock 70kDa protein 1A 31 10
HSPA1B 0161 heat shock 70kDa protein 1B 4 0
HSPA8 0199 heat shock 70kDa protein 8 12 5
HSPA9 0152 heat shock 70kDa protein 9 (mortalin) 4 1
HSPD1 0159 heat shock 60kDa protein 1 (chaperonin) 6 2
HTT 0098 huntingtin 17 6
IGF1 0028 insulin-like growth factor 1 (somatomedin C) 118 2
IGF1R 0015 insulin-like growth factor 1 receptor 36 12
IGF2 0029 insulin-like growth factor 2 (somatomedin A) 21 2
IGFBP2 0279 insulin-like growth factor binding protein 2, 36kDa 1 0
IGFBP3 0073 insulin-like growth factor binding protein 3 10 2
IL2 0046 interleukin 2 7 2
IL2RG 0049 interleukin 2 receptor, gamma (severe combined immunodeficiency) 2 4
IL6 0144 interleukin 6 (interferon, beta 2) 23 2
IL7 0167 interleukin 7 6 2
IL7R 0027 interleukin 7 receptor 5 6
INS 0030 insulin 77 5
INSR 0042 insulin receptor 33 11
IRS1 0032 insulin receptor substrate 1 21 9
IRS2 0034 insulin receptor substrate 2 16 10
JAK2 0215 Janus kinase 2 9 13
JUN 0172 jun oncogene 22 22
JUND 0045 jun D proto-oncogene 7 7
KCNA3 0268 potassium voltage-gated channel, shaker-related subfamily, member 3 6 1
KL 0017 klotho 33 0
LEP 0217 leptin 36 3
LEPR 0218 leptin receptor 14 4
LMNA 0014 lamin A/C 61 4
LMNB1 0181 lamin B1 5 3
LRP2 0134 low density lipoprotein receptor-related protein 2 2 4
MAP3K5 0179 mitogen-activated protein kinase kinase kinase 5 4 5
MAPK14 0168 mitogen-activated protein kinase 14 28 6
MAPK3 0175 mitogen-activated protein kinase 3 12 4
MAPK8 0163 mitogen-activated protein kinase 8 26 11
MAPK9 0174 mitogen-activated protein kinase 9 16 6
MAPT 0205 microtubule-associated protein tau 35 5
MAX 0208 MYC associated factor X 5 4
MDM2 0210 Mdm2 p53 binding protein homolog (mouse) 9 11
MED1 0173 mediator complex subunit 1 2 5
MLH1 0243 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 5 3
MSRA 0127 methionine sulfoxide reductase A 11 0
MT-CO1 0158 mitochondrially encoded cytochrome c oxidase I 5 0
MTOR 0221 mechanistic target of rapamycin (serine/threonine kinase) 26 0
MXD1 0209 MAX dimerization protein 1 2 5
MXI1 0090 MAX interactor 1 3 2
MYC 0039 v-myc myelocytomatosis viral oncogene homolog (avian) 22 12
NBN 0044 nibrin 22 9
NCOR1 0043 nuclear receptor co-repressor 1 6 9
NCOR2 0276 nuclear receptor corepressor 2 1 8
NFE2L2 0283 nuclear factor (erythroid-derived 2)-like 2 7 2
NFKB1 0082 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 25 11
NFKB2 0020 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 24 3
NFKBIA 0219 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 9 5
NGF 0031 nerve growth factor (beta polypeptide) 13 2
NGFR 0037 nerve growth factor receptor (TNFR superfamily, member 16) 5 2
NOG 0229 noggin 7 0
NR3C1 0075 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 14 23
NRG1 0024 neuregulin 1 6 3
PAPPA 0254 pregnancy-associated plasma protein A, pappalysin 1 8 0
PARP1 0060 poly (ADP-ribose) polymerase 1 39 7
PCK1 0248 phosphoenolpyruvate carboxykinase 1 (soluble) 2 0
PCMT1 0162 protein-L-isoaspartate (D-aspartate) O-methyltransferase 5 0
PCNA 0113 proliferating cell nuclear antigen 12 20
PDGFB 0047 platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 7 3
PDGFRA 0285 platelet-derived growth factor receptor, alpha polypeptide 4 3
PDGFRB 0051 platelet-derived growth factor receptor, beta polypeptide 4 7
PDPK1 0087 3-phosphoinositide dependent protein kinase-1 4 3
PEX5 0058 peroxisomal biogenesis factor 5 4 2
PIK3CA 0286 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1 1
PIK3CB 0036 phosphoinositide-3-kinase, catalytic, beta polypeptide 22 2
PIK3R1 0185 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 16 13
PIN1 0062 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 9 3
PLAU 0010 plasminogen activator, urokinase 9 1
PLCG2 0057 phospholipase C, gamma 2 (phosphatidylinositol-specific) 6 2
PMCH 0242 pro-melanin-concentrating hormone 6 0
PML 0096 promyelocytic leukemia 11 13
POLA1 0204 polymerase (DNA directed), alpha 1, catalytic subunit 9 3
POLB 0236 polymerase (DNA directed), beta 14 3
POLD1 0118 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 11 2
POLG 0072 polymerase (DNA directed), gamma 11 0
PON1 0142 paraoxonase 1 10 1
POU1F1 0004 POU class 1 homeobox 1 20 4
PPARA 0055 peroxisome proliferator-activated receptor alpha 13 7
PPARG 0263 peroxisome proliferator-activated receptor gamma 8 2
PPARGC1A 0256 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 15 4
PPM1D 0246 protein phosphatase, Mg2+/Mn2+ dependent, 1D 1 0
PPP1CA 0227 protein phosphatase 1, catalytic subunit, alpha isozyme 3 2
PRDX1 0141 peroxiredoxin 1 4 0
PRKCA 0099 protein kinase C, alpha 4 12
PRKCD 0054 protein kinase C, delta 4 7
PRKDC 0106 protein kinase, DNA-activated, catalytic polypeptide 16 12
PROP1 0005 PROP paired-like homeobox 1 29 2
PSEN1 0224 presenilin 1 18 4
PTEN 0063 phosphatase and tensin homolog 16 3
PTGS2 0198 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 11 1
PTK2 0166 PTK2 protein tyrosine kinase 2 5 7
PTK2B 0165 PTK2B protein tyrosine kinase 2 beta 2 7
PTPN1 0033 protein tyrosine phosphatase, non-receptor type 1 5 6
PTPN11 0019 protein tyrosine phosphatase, non-receptor type 11 7 10
PYCR1 0280 pyrroline-5-carboxylate reductase 1 1 0
RAD51 0084 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 10 6
RAD52 0147 RAD52 homolog (S. cerevisiae) 3 3
RAE1 0241 RAE1 RNA export 1 homolog (S. pombe) 2 0
RB1 0120 retinoblastoma 1 46 20
RECQL4 0128 RecQ protein-like 4 11 0
RELA 0143 v-rel reticuloendotheliosis viral oncogene homolog A (avian) 32 22
RET 0056 ret proto-oncogene 4 3
RFC4 0108 replication factor C (activator 1) 4, 37kDa 1 6
RGN 0145 regucalcin (senescence marker protein-30) 6 0
RPA1 0067 replication protein A1, 70kDa 5 5
S100B 0070 S100 calcium binding protein B 7 2
SDHC 0182 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 5 0
SHC1 0003 SHC (Src homology 2 domain containing) transforming protein 1 29 28
SIN3A 0200 SIN3 homolog A, transcription regulator (yeast) 3 6
SIRT1 0150 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) 82 1
SIRT3 0275 sirtuin 3 4 0
SIRT6 0239 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) 15 0
SIRT7 0269 sirtuin 7 3 0
SLC13A1 0270 solute carrier family 13 (sodium/sulfate symporters), member 1 3 0
SNCG 0140 synuclein, gamma (breast cancer-specific protein 1) 5 3
SOCS2 0271 suppressor of cytokine signaling 2 7 3
SOD1 0130 superoxide dismutase 1, soluble 45 1
SOD2 0129 superoxide dismutase 2, mitochondrial 55 0
SP1 0170 Sp1 transcription factor 13 13
SST 0053 somatostatin 8 2
SSTR3 0100 somatostatin receptor 3 2 2
STAT3 0022 signal transducer and activator of transcription 3 (acute-phase response factor) 13 15
STAT5A 0023 signal transducer and activator of transcription 5A 5 13
STAT5B 0021 signal transducer and activator of transcription 5B 5 6
STK11 0093 serine/threonine kinase 11 5 2
STUB1 0245 STIP1 homology and U-box containing protein 1 1 5
SUMO1 0211 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 6 16
SUN1 0277 Sad1 and UNC84 domain containing 1 1 0
TAF1 0180 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 1 9
TBP 0194 TATA box binding protein 6 11
TCF3 0059 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 7 2
TERC 0007 telomerase RNA component 34 2
TERF1 0105 telomeric repeat binding factor (NIMA-interacting) 1 9 2
TERF2 0116 telomeric repeat binding factor 2 18 3
TERT 0008 telomerase reverse transcriptase 62 6
TFAP2A 0190 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 7 2
TFDP1 0202 transcription factor Dp-1 4 4
TGFB1 0091 transforming growth factor, beta 1 25 2
TNF 0086 tumor necrosis factor (TNF superfamily, member 2) 20 5
TOP1 0083 topoisomerase (DNA) I 9 6
TOP2A 0080 topoisomerase (DNA) II alpha 170kDa 8 6
TOP2B 0081 topoisomerase (DNA) II beta 180kDa 8 4
TOP3B 0148 topoisomerase (DNA) III beta 7 0
TOPORS 0272 topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 2 4
TP53 0006 tumor protein p53 139 63
TP53BP1 0274 tumor protein p53 binding protein 1 7 6
TP63 0234 tumor protein p63 9 1
TP73 0281 tumor protein p73 3 9
TPP2 0273 tripeptidyl peptidase II 2 0
TXN 0016 thioredoxin 15 3
UBB 0066 ubiquitin B 8 1
UBE2I 0085 ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 5 11
UCHL1 0136 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 6 1
UCP1 0258 uncoupling protein 1 (mitochondrial, proton carrier) 5 0
UCP2 0235 uncoupling protein 2 (mitochondrial, proton carrier) 22 1
UCP3 0232 uncoupling protein 3 (mitochondrial, proton carrier) 22 1
VCP 0071 valosin-containing protein 3 4
VEGFA 0077 vascular endothelial growth factor A 15 2
WRN 0013 Werner syndrome, RecQ helicase-like 88 20
XPA 0126 xeroderma pigmentosum, complementation group A 15 3
XRCC5 0112 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 24 6
XRCC6 0117 X-ray repair complementing defective repair in Chinese hamster cells 6 19 12
YWHAZ 0164 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 3 13
ZMPSTE24 0233 zinc metallopeptidase (STE24 homolog, S. cerevisiae) 13 0

Entry selected based on evidence directly linking the gene product to ageing in humans
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Entry selected based on evidence linking the gene or its product to human longevity and/or multiple age-related phenotypes
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing or showing the gene product to be an effector of genes related to ageing