| HGNC Symbol |
HAGRID |
Common name |
Function(s) |
References |
Interactions |
|
|
|
|
|
|
| A2M |
0139 |
alpha-2-macroglobulin |
stress response, other |
5 |
3 |
| ABL1 |
0078 |
c-abl oncogene 1, receptor tyrosine kinase |
transcriptional regulation, cell cycle control, growth and development |
5 |
7 |
| ADCY5 |
0255 |
adenylate cyclase 5 |
energy apparatus, other |
1 |
1 |
| AGPAT2 |
0187 |
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) |
energy apparatus |
3 |
0 |
| AIFM1 |
0135 |
apoptosis-inducing factor, mitochondrion-associated, 1 |
DNA condensation, apoptosis, redox and oxidative regulation |
4 |
1 |
| AKT1 |
0035 |
v-akt murine thymoma viral oncogene homolog 1 |
apoptosis, growth and development, signalling |
43 |
12 |
| APEX1 |
0195 |
APEX nuclease (multifunctional DNA repair enzyme) 1 |
DNA repair, redox and oxidative regulation |
11 |
8 |
| APOC3 |
0102 |
apolipoprotein C-III |
energy apparatus, other |
6 |
0 |
| APOE |
0138 |
apolipoprotein E |
energy apparatus, other |
26 |
3 |
| APP |
0137 |
amyloid beta (A4) precursor protein |
transcriptional regulation, growth and development, signalling, other |
33 |
3 |
| APTX |
0095 |
aprataxin |
DNA repair, stress response |
6 |
3 |
| AR |
0110 |
androgen receptor |
apoptosis, growth and development |
8 |
20 |
| ARHGAP1 |
0249 |
Rho GTPase activating protein 1 |
signalling |
1 |
1 |
| ARNTL |
0251 |
aryl hydrocarbon receptor nuclear translocator-like |
transcriptional regulation, signalling, other |
6 |
3 |
| ATF2 |
0193 |
activating transcription factor 2 |
DNA repair, transcriptional regulation, cell cycle control, signalling |
10 |
10 |
| ATM |
0009 |
ataxia telangiectasia mutated |
DNA repair, stress response, cell cycle control |
38 |
13 |
| ATP5O |
0146 |
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
energy apparatus |
3 |
0 |
| ATR |
0231 |
ataxia telangiectasia and Rad3 related |
DNA repair, apoptosis, cell cycle control |
5 |
4 |
| BAX |
0119 |
BCL2-associated X protein |
apoptosis |
21 |
1 |
| BCL2 |
0069 |
B-cell CLL/lymphoma 2 |
apoptosis |
30 |
6 |
| BDNF |
0191 |
brain-derived neurotrophic factor |
energy apparatus, growth and development |
26 |
1 |
| BLM |
0068 |
Bloom syndrome, RecQ helicase-like |
DNA repair, DNA condensation, DNA replication |
15 |
9 |
| BMI1 |
0188 |
BMI1 polycomb ring finger oncogene |
DNA condensation, cell cycle control |
8 |
0 |
| BRCA1 |
0061 |
breast cancer 1, early onset |
DNA repair, DNA condensation, apoptosis, transcriptional regulation |
19 |
27 |
| BRCA2 |
0079 |
breast cancer 2, early onset |
DNA repair, growth and development |
8 |
4 |
| BSCL2 |
0186 |
Berardinelli-Seip congenital lipodystrophy 2 (seipin) |
other |
3 |
0 |
| BUB1B |
0197 |
budding uninhibited by benzimidazoles 1 homolog beta (yeast) |
DNA replication, cell cycle control |
9 |
3 |
| BUB3 |
0240 |
budding uninhibited by benzimidazoles 3 homolog (yeast) |
DNA replication, cell cycle control |
4 |
1 |
| CACNA1A |
0133 |
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit |
calcium metabolism |
7 |
0 |
| CAT |
0107 |
catalase |
redox and oxidative regulation |
35 |
1 |
| CCNA2 |
0177 |
cyclin A2 |
cell cycle control, growth and development |
3 |
7 |
| CDC42 |
0250 |
cell division cycle 42 (GTP binding protein, 25kDa) |
cell cycle control, signalling, other |
2 |
3 |
| CDK1 |
0201 |
cyclin-dependent kinase 1 |
apoptosis, cell cycle control |
4 |
5 |
| CDKN2A |
0226 |
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) |
cell cycle control |
28 |
1 |
| CEBPA |
0088 |
CCAAT/enhancer binding protein (C/EBP), alpha |
energy apparatus, transcriptional regulation, cell cycle control |
12 |
6 |
| CEBPB |
0089 |
CCAAT/enhancer binding protein (C/EBP), beta |
energy apparatus, transcriptional regulation, cell cycle control |
8 |
16 |
| CHEK2 |
0247 |
CHK2 checkpoint homolog (S. pombe) |
DNA replication, cell cycle control |
6 |
6 |
| CLOCK |
0252 |
clock homolog (mouse) |
transcriptional regulation, signalling, other |
11 |
1 |
| CLU |
0220 |
clusterin |
apoptosis, other |
13 |
6 |
| COQ7 |
0132 |
coenzyme Q7 homolog, ubiquinone (yeast) |
energy apparatus, other |
10 |
0 |
| CREB1 |
0192 |
cAMP responsive element binding protein 1 |
transcriptional regulation, growth and development |
14 |
5 |
| CREBBP |
0064 |
CREB binding protein |
apoptosis, transcriptional regulation |
11 |
17 |
| CSNK1E |
0244 |
casein kinase 1, epsilon |
signalling, other |
7 |
0 |
| CTGF |
0206 |
connective tissue growth factor |
growth and development, other |
3 |
2 |
| CTNNB1 |
0223 |
catenin (cadherin-associated protein), beta 1, 88kDa |
transcriptional regulation, growth and development, signalling |
16 |
9 |
| DBN1 |
0228 |
drebrin 1 |
cell cycle control, other |
4 |
0 |
| DDIT3 |
0203 |
DNA-damage-inducible transcript 3 |
apoptosis, stress response, transcriptional regulation |
4 |
4 |
| DLL3 |
0225 |
delta-like 3 (Drosophila) |
growth and development, signalling |
12 |
0 |
| E2F1 |
0018 |
E2F transcription factor 1 |
apoptosis, transcriptional regulation, cell cycle control |
14 |
7 |
| EEF1A1 |
0189 |
eukaryotic translation elongation factor 1 alpha 1 |
growth and development, other |
5 |
0 |
| EEF2 |
0103 |
eukaryotic translation elongation factor 2 |
growth and development, other |
5 |
1 |
| EFEMP1 |
0260 |
EGF-containing fibulin-like extracellular matrix protein 1 |
other |
3 |
0 |
| EGF |
0048 |
epidermal growth factor (beta-urogastrone) |
growth and development |
15 |
6 |
| EGFR |
0040 |
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) |
apoptosis, cell cycle control, growth and development |
13 |
14 |
| EGR1 |
0076 |
early growth response 1 |
apoptosis, cell cycle control |
5 |
4 |
| ELN |
0230 |
elastin |
other |
9 |
0 |
| EMD |
0121 |
emerin |
cell cycle control, other |
4 |
1 |
| EP300 |
0094 |
E1A binding protein p300 |
DNA repair, DNA condensation, cell cycle control |
10 |
20 |
| EPOR |
0052 |
erythropoietin receptor |
growth and development, signalling |
5 |
5 |
| ERBB2 |
0041 |
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
apoptosis, growth and development, signalling |
9 |
10 |
| ERCC1 |
0149 |
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) |
DNA repair |
11 |
2 |
| ERCC2 |
0011 |
excision repair cross-complementing rodent repair deficiency, complementation group 2 |
DNA repair, DNA condensation |
19 |
5 |
| ERCC3 |
0104 |
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) |
DNA repair, DNA condensation |
10 |
4 |
| ERCC4 |
0261 |
excision repair cross-complementing rodent repair deficiency, complementation group 4 |
DNA repair |
6 |
2 |
| ERCC5 |
0109 |
excision repair cross-complementing rodent repair deficiency, complementation group 5 |
DNA repair |
5 |
4 |
| ERCC6 |
0092 |
excision repair cross-complementing rodent repair deficiency, complementation group 6 |
DNA repair, DNA condensation |
16 |
5 |
| ERCC8 |
0012 |
excision repair cross-complementing rodent repair deficiency, complementation group 8 |
DNA repair, other |
10 |
2 |
| ESR1 |
0216 |
estrogen receptor 1 |
transcriptional regulation, signalling |
23 |
14 |
| FAS |
0115 |
Fas (TNF receptor superfamily, member 6) |
apoptosis, growth and development, signalling |
26 |
1 |
| FEN1 |
0114 |
flap structure-specific endonuclease 1 |
other |
10 |
4 |
| FGF23 |
0259 |
fibroblast growth factor 23 |
signalling |
6 |
0 |
| FGFR1 |
0169 |
fibroblast growth factor receptor 1 |
signalling |
8 |
2 |
| FLT1 |
0171 |
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
growth and development, signalling |
3 |
3 |
| FOS |
0050 |
FBJ murine osteosarcoma viral oncogene homolog |
apoptosis, stress response, transcriptional regulation, cell cycle control, growth and development |
19 |
8 |
| FOXM1 |
0131 |
forkhead box M1 |
redox and oxidative regulation, cell cycle control, growth and development |
21 |
1 |
| FOXO1 |
0124 |
forkhead box O1 |
apoptosis, growth and development |
39 |
5 |
| FOXO3 |
0123 |
forkhead box O3 |
DNA repair, apoptosis, stress response, growth and development |
51 |
2 |
| FOXO4 |
0183 |
forkhead box O4 |
cell cycle control, growth and development |
19 |
3 |
| GCLC |
0237 |
glutamate-cysteine ligase, catalytic subunit |
redox and oxidative regulation, other |
7 |
1 |
| GCLM |
0238 |
glutamate-cysteine ligase, modifier subunit |
redox and oxidative regulation, other |
6 |
1 |
| GH1 |
0026 |
growth hormone 1 |
growth and development |
65 |
1 |
| GHR |
0001 |
growth hormone receptor |
growth and development, signalling |
29 |
11 |
| GHRH |
0002 |
growth hormone releasing hormone |
growth and development |
14 |
3 |
| GHRHR |
0222 |
growth hormone releasing hormone receptor |
growth and development, signalling |
15 |
1 |
| GPX1 |
0153 |
glutathione peroxidase 1 |
redox and oxidative regulation |
25 |
1 |
| GPX4 |
0257 |
glutathione peroxidase 4 (phospholipid hydroperoxidase) |
redox and oxidative regulation |
2 |
0 |
| GRB2 |
0122 |
growth factor receptor-bound protein 2 |
signalling, other |
7 |
23 |
| GSK3B |
0097 |
glycogen synthase kinase 3 beta |
energy apparatus, apoptosis, growth and development |
7 |
3 |
| GSR |
0154 |
glutathione reductase |
redox and oxidative regulation |
12 |
0 |
| GSS |
0155 |
glutathione synthetase |
redox and oxidative regulation |
6 |
0 |
| GSTA4 |
0156 |
glutathione S-transferase alpha 4 |
redox and oxidative regulation |
8 |
0 |
| GSTP1 |
0157 |
glutathione S-transferase pi 1 |
redox and oxidative regulation |
13 |
1 |
| GTF2H2 |
0111 |
general transcription factor IIH, polypeptide 2, 44kDa |
DNA repair |
3 |
3 |
| H2AFX |
0212 |
H2A histone family, member X |
DNA repair, DNA condensation, DNA replication |
11 |
3 |
| HBP1 |
0196 |
HMG-box transcription factor 1 |
DNA condensation, transcriptional regulation |
5 |
4 |
| HDAC1 |
0151 |
histone deacetylase 1 |
transcriptional regulation, cell cycle control, growth and development |
8 |
20 |
| HDAC2 |
0207 |
histone deacetylase 2 |
transcriptional regulation, cell cycle control, growth and development |
5 |
7 |
| HDAC3 |
0025 |
histone deacetylase 3 |
transcriptional regulation, cell cycle control, growth and development |
7 |
7 |
| HELLS |
0101 |
helicase, lymphoid-specific |
DNA condensation, transcriptional regulation |
6 |
0 |
| HESX1 |
0184 |
HESX homeobox 1 |
growth and development |
4 |
2 |
| HIC1 |
0253 |
hypermethylated in cancer 1 |
transcriptional regulation, signalling |
2 |
1 |
| HIF1A |
0065 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
redox and oxidative regulation, transcriptional regulation, growth and development |
13 |
6 |
| HMGB1 |
0176 |
high-mobility group box 1 |
DNA repair, DNA condensation, stress response, signalling |
8 |
11 |
| HMGB2 |
0178 |
high-mobility group box 2 |
DNA repair, DNA condensation, DNA replication, stress response, signalling |
4 |
3 |
| HOXB7 |
0213 |
homeobox B7 |
transcriptional regulation, growth and development |
5 |
2 |
| HOXC4 |
0214 |
homeobox C4 |
transcriptional regulation, growth and development |
4 |
2 |
| HRAS |
0038 |
v-Ha-ras Harvey rat sarcoma viral oncogene homolog |
apoptosis, cell cycle control, growth and development, other |
21 |
6 |
| HSF1 |
0125 |
heat shock transcription factor 1 |
stress response, transcriptional regulation |
22 |
10 |
| HSP90AA1 |
0074 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 |
stress response |
10 |
15 |
| HSPA1A |
0160 |
heat shock 70kDa protein 1A |
stress response |
30 |
10 |
| HSPA1B |
0161 |
heat shock 70kDa protein 1B |
stress response, signalling |
4 |
0 |
| HSPA8 |
0199 |
heat shock 70kDa protein 8 |
stress response |
12 |
5 |
| HSPA9 |
0152 |
heat shock 70kDa protein 9 (mortalin) |
apoptosis, stress response |
4 |
1 |
| HSPD1 |
0159 |
heat shock 60kDa protein 1 (chaperonin) |
apoptosis, stress response |
6 |
1 |
| HTT |
0098 |
huntingtin |
apoptosis, other |
16 |
6 |
| IGF1 |
0028 |
insulin-like growth factor 1 (somatomedin C) |
growth and development, calcium metabolism |
109 |
2 |
| IGF1R |
0015 |
insulin-like growth factor 1 receptor |
growth and development |
33 |
11 |
| IGF2 |
0029 |
insulin-like growth factor 2 (somatomedin A) |
growth and development, signalling |
20 |
2 |
| IGFBP3 |
0073 |
insulin-like growth factor binding protein 3 |
apoptosis, growth and development |
10 |
2 |
| IL2 |
0046 |
interleukin 2 |
apoptosis, signalling, other |
6 |
2 |
| IL2RG |
0049 |
interleukin 2 receptor, gamma (severe combined immunodeficiency) |
signalling |
2 |
4 |
| IL6 |
0144 |
interleukin 6 (interferon, beta 2) |
growth and development, signalling, other |
23 |
2 |
| IL7 |
0167 |
interleukin 7 |
growth and development, other |
6 |
2 |
| IL7R |
0027 |
interleukin 7 receptor |
signalling, other |
5 |
6 |
| INS |
0030 |
insulin |
growth and development |
76 |
5 |
| INSR |
0042 |
insulin receptor |
energy apparatus, apoptosis, signalling |
33 |
11 |
| IRS1 |
0032 |
insulin receptor substrate 1 |
apoptosis, growth and development, signalling |
19 |
9 |
| IRS2 |
0034 |
insulin receptor substrate 2 |
energy apparatus, signalling |
16 |
9 |
| JAK2 |
0215 |
Janus kinase 2 |
signalling |
9 |
13 |
| JUN |
0172 |
jun oncogene |
apoptosis, stress response, cell cycle control |
22 |
22 |
| JUND |
0045 |
jun D proto-oncogene |
transcriptional regulation, cell cycle control |
5 |
6 |
| KL |
0017 |
klotho |
calcium metabolism, signalling, other |
28 |
0 |
| LEP |
0217 |
leptin |
energy apparatus |
36 |
3 |
| LEPR |
0218 |
leptin receptor |
signalling |
13 |
4 |
| LMNA |
0014 |
lamin A/C |
DNA repair, DNA condensation, apoptosis, transcriptional regulation, other |
52 |
4 |
| LMNB1 |
0181 |
lamin B1 |
DNA condensation, DNA replication, apoptosis, other |
5 |
3 |
| LRP2 |
0134 |
low density lipoprotein receptor-related protein 2 |
energy apparatus, other |
2 |
4 |
| MAP3K5 |
0179 |
mitogen-activated protein kinase kinase kinase 5 |
apoptosis, stress response, signalling |
4 |
4 |
| MAPK14 |
0168 |
mitogen-activated protein kinase 14 |
apoptosis, stress response, transcriptional regulation |
26 |
6 |
| MAPK3 |
0175 |
mitogen-activated protein kinase 3 |
stress response, cell cycle control, signalling |
11 |
4 |
| MAPK8 |
0163 |
mitogen-activated protein kinase 8 |
apoptosis, stress response |
26 |
10 |
| MAPK9 |
0174 |
mitogen-activated protein kinase 9 |
apoptosis, stress response |
16 |
6 |
| MAPT |
0205 |
microtubule-associated protein tau |
other |
33 |
5 |
| MAX |
0208 |
MYC associated factor X |
apoptosis, transcriptional regulation, cell cycle control |
5 |
4 |
| MDM2 |
0210 |
Mdm2 p53 binding protein homolog (mouse) |
apoptosis, cell cycle control |
9 |
10 |
| MED1 |
0173 |
mediator complex subunit 1 |
growth and development, signalling |
2 |
5 |
| MLH1 |
0243 |
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
DNA repair |
5 |
3 |
| MSRA |
0127 |
methionine sulfoxide reductase A |
stress response, redox and oxidative regulation |
11 |
0 |
| MT-CO1 |
0158 |
mitochondrially encoded cytochrome c oxidase I |
energy apparatus, other |
5 |
0 |
| MTOR |
0221 |
mechanistic target of rapamycin (serine/threonine kinase) |
cell cycle control, growth and development, signalling |
20 |
0 |
| MXD1 |
0209 |
MAX dimerization protein 1 |
DNA condensation, apoptosis, transcriptional regulation, cell cycle control |
2 |
5 |
| MXI1 |
0090 |
MAX interactor 1 |
transcriptional regulation |
3 |
2 |
| MYC |
0039 |
v-myc myelocytomatosis viral oncogene homolog (avian) |
apoptosis, cell cycle control, growth and development |
22 |
11 |
| NBN |
0044 |
nibrin |
DNA repair, cell cycle control |
22 |
9 |
| NCOR1 |
0043 |
nuclear receptor co-repressor 1 |
DNA condensation, growth and development |
4 |
9 |
| NFKB1 |
0082 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
apoptosis, stress response, redox and oxidative regulation |
23 |
9 |
| NFKB2 |
0020 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
apoptosis, stress response, redox and oxidative regulation |
22 |
3 |
| NFKBIA |
0219 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
apoptosis, growth and development, signalling |
8 |
5 |
| NGF |
0031 |
nerve growth factor (beta polypeptide) |
growth and development |
13 |
2 |
| NGFR |
0037 |
nerve growth factor receptor (TNFR superfamily, member 16) |
apoptosis, growth and development, signalling |
5 |
2 |
| NOG |
0229 |
noggin |
growth and development |
7 |
0 |
| NR3C1 |
0075 |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
stress response, transcriptional regulation, signalling |
14 |
22 |
| NRG1 |
0024 |
neuregulin 1 |
apoptosis, growth and development |
6 |
3 |
| PAPPA |
0254 |
pregnancy-associated plasma protein A, pappalysin 1 |
cell cycle control, other |
6 |
0 |
| PARP1 |
0060 |
poly (ADP-ribose) polymerase 1 |
DNA repair, DNA condensation, DNA replication, apoptosis, other |
34 |
7 |
| PCK1 |
0248 |
phosphoenolpyruvate carboxykinase 1 (soluble) |
energy apparatus, other |
2 |
0 |
| PCMT1 |
0162 |
protein-L-isoaspartate (D-aspartate) O-methyltransferase |
stress response, other |
5 |
0 |
| PCNA |
0113 |
proliferating cell nuclear antigen |
DNA repair, DNA replication, cell cycle control |
12 |
20 |
| PDGFB |
0047 |
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) |
apoptosis, growth and development |
7 |
3 |
| PDGFRB |
0051 |
platelet-derived growth factor receptor, beta polypeptide |
growth and development, signalling |
4 |
6 |
| PDPK1 |
0087 |
3-phosphoinositide dependent protein kinase-1 |
growth and development, signalling |
4 |
3 |
| PEX5 |
0058 |
peroxisomal biogenesis factor 5 |
redox and oxidative regulation, signalling |
4 |
2 |
| PIK3CB |
0036 |
phosphoinositide-3-kinase, catalytic, beta polypeptide |
stress response, signalling |
22 |
2 |
| PIK3R1 |
0185 |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
energy apparatus, apoptosis, growth and development, signalling |
16 |
13 |
| PIN1 |
0062 |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
DNA replication, apoptosis, cell cycle control |
9 |
3 |
| PLAU |
0010 |
plasminogen activator, urokinase |
growth and development, other |
9 |
1 |
| PLCG2 |
0057 |
phospholipase C, gamma 2 (phosphatidylinositol-specific) |
growth and development, signalling |
6 |
2 |
| PMCH |
0242 |
pro-melanin-concentrating hormone |
signalling, other |
5 |
0 |
| PML |
0096 |
promyelocytic leukemia |
apoptosis, transcriptional regulation, cell cycle control |
11 |
11 |
| POLA1 |
0204 |
polymerase (DNA directed), alpha 1, catalytic subunit |
DNA repair, DNA replication |
5 |
3 |
| POLB |
0236 |
polymerase (DNA directed), beta |
DNA repair, DNA replication |
13 |
3 |
| POLD1 |
0118 |
polymerase (DNA directed), delta 1, catalytic subunit 125kDa |
DNA repair, DNA replication |
11 |
2 |
| POLG |
0072 |
polymerase (DNA directed), gamma |
DNA repair, DNA replication |
11 |
0 |
| PON1 |
0142 |
paraoxonase 1 |
stress response, redox and oxidative regulation |
9 |
1 |
| POU1F1 |
0004 |
POU class 1 homeobox 1 |
transcriptional regulation, growth and development |
20 |
4 |
| PPARA |
0055 |
peroxisome proliferator-activated receptor alpha |
energy apparatus, apoptosis, redox and oxidative regulation, transcriptional regulation, other |
12 |
6 |
| PPARGC1A |
0256 |
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
energy apparatus, transcriptional regulation, other |
13 |
4 |
| PPM1D |
0246 |
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
stress response, cell cycle control |
1 |
0 |
| PPP1CA |
0227 |
protein phosphatase 1, catalytic subunit, alpha isozyme |
growth and development, other |
3 |
2 |
| PRDX1 |
0141 |
peroxiredoxin 1 |
redox and oxidative regulation, signalling |
4 |
0 |
| PRKCA |
0099 |
protein kinase C, alpha |
signalling, other |
4 |
12 |
| PRKCD |
0054 |
protein kinase C, delta |
apoptosis, transcriptional regulation, other |
4 |
7 |
| PRKDC |
0106 |
protein kinase, DNA-activated, catalytic polypeptide |
DNA repair, apoptosis, transcriptional regulation |
16 |
12 |
| PROP1 |
0005 |
PROP paired-like homeobox 1 |
growth and development |
24 |
2 |
| PSEN1 |
0224 |
presenilin 1 |
signalling, other |
17 |
4 |
| PTEN |
0063 |
phosphatase and tensin homolog |
apoptosis, cell cycle control, growth and development |
16 |
3 |
| PTGS2 |
0198 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
signalling, other |
11 |
1 |
| PTK2 |
0166 |
PTK2 protein tyrosine kinase 2 |
apoptosis, stress response, signalling |
5 |
7 |
| PTK2B |
0165 |
PTK2B protein tyrosine kinase 2 beta |
stress response, calcium metabolism, signalling |
2 |
7 |
| PTPN1 |
0033 |
protein tyrosine phosphatase, non-receptor type 1 |
energy apparatus, growth and development, signalling |
5 |
6 |
| PTPN11 |
0019 |
protein tyrosine phosphatase, non-receptor type 11 |
growth and development, signalling |
7 |
10 |
| RAD51 |
0084 |
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) |
DNA repair, DNA condensation |
10 |
6 |
| RAD52 |
0147 |
RAD52 homolog (S. cerevisiae) |
DNA repair |
3 |
3 |
| RAE1 |
0241 |
RAE1 RNA export 1 homolog (S. pombe) |
other |
2 |
0 |
| RB1 |
0120 |
retinoblastoma 1 |
apoptosis, transcriptional regulation, cell cycle control |
46 |
20 |
| RECQL4 |
0128 |
RecQ protein-like 4 |
DNA repair, DNA condensation |
11 |
0 |
| RELA |
0143 |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
apoptosis, transcriptional regulation |
29 |
20 |
| RET |
0056 |
ret proto-oncogene |
growth and development |
4 |
3 |
| RFC4 |
0108 |
replication factor C (activator 1) 4, 37kDa |
DNA repair, DNA replication |
1 |
6 |
| RGN |
0145 |
regucalcin (senescence marker protein-30) |
apoptosis, calcium metabolism, other |
6 |
0 |
| RPA1 |
0067 |
replication protein A1, 70kDa |
DNA repair, DNA replication |
5 |
5 |
| S100B |
0070 |
S100 calcium binding protein B |
energy apparatus, apoptosis, calcium metabolism, other |
7 |
2 |
| SDHC |
0182 |
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa |
energy apparatus, other |
5 |
0 |
| SHC1 |
0003 |
SHC (Src homology 2 domain containing) transforming protein 1 |
apoptosis, stress response, redox and oxidative regulation, growth and development, signalling |
24 |
28 |
| SIN3A |
0200 |
SIN3 homolog A, transcription regulator (yeast) |
transcriptional regulation |
3 |
6 |
| SIRT1 |
0150 |
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
DNA condensation, energy apparatus, stress response |
60 |
1 |
| SIRT6 |
0239 |
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) |
DNA repair, DNA condensation |
6 |
0 |
| SNCG |
0140 |
synuclein, gamma (breast cancer-specific protein 1) |
other |
5 |
3 |
| SOD1 |
0130 |
superoxide dismutase 1, soluble |
redox and oxidative regulation |
45 |
1 |
| SOD2 |
0129 |
superoxide dismutase 2, mitochondrial |
redox and oxidative regulation |
46 |
0 |
| SP1 |
0170 |
Sp1 transcription factor |
transcriptional regulation |
13 |
13 |
| SST |
0053 |
somatostatin |
growth and development, calcium metabolism |
8 |
2 |
| SSTR3 |
0100 |
somatostatin receptor 3 |
apoptosis, growth and development, signalling |
2 |
2 |
| STAT3 |
0022 |
signal transducer and activator of transcription 3 (acute-phase response factor) |
apoptosis, transcriptional regulation, signalling |
11 |
14 |
| STAT5A |
0023 |
signal transducer and activator of transcription 5A |
signalling |
5 |
12 |
| STAT5B |
0021 |
signal transducer and activator of transcription 5B |
transcriptional regulation, signalling |
5 |
5 |
| STK11 |
0093 |
serine/threonine kinase 11 |
apoptosis |
5 |
2 |
| STUB1 |
0245 |
STIP1 homology and U-box containing protein 1 |
other |
1 |
5 |
| SUMO1 |
0211 |
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) |
DNA repair, apoptosis, transcriptional regulation |
5 |
14 |
| TAF1 |
0180 |
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
apoptosis, transcriptional regulation, cell cycle control, other |
1 |
9 |
| TBP |
0194 |
TATA box binding protein |
transcriptional regulation, growth and development |
6 |
11 |
| TCF3 |
0059 |
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) |
apoptosis, transcriptional regulation, growth and development |
7 |
2 |
| TERC |
0007 |
telomerase RNA component |
DNA repair, DNA replication, cell cycle control |
32 |
2 |
| TERF1 |
0105 |
telomeric repeat binding factor (NIMA-interacting) 1 |
DNA replication, apoptosis, cell cycle control |
8 |
2 |
| TERF2 |
0116 |
telomeric repeat binding factor 2 |
DNA repair, cell cycle control |
15 |
3 |
| TERT |
0008 |
telomerase reverse transcriptase |
DNA repair, DNA replication, cell cycle control |
50 |
6 |
| TFAP2A |
0190 |
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
transcriptional regulation, growth and development |
7 |
2 |
| TFDP1 |
0202 |
transcription factor Dp-1 |
apoptosis, transcriptional regulation, cell cycle control |
4 |
4 |
| TGFB1 |
0091 |
transforming growth factor, beta 1 |
cell cycle control, growth and development |
25 |
2 |
| TNF |
0086 |
tumor necrosis factor (TNF superfamily, member 2) |
apoptosis, other |
19 |
5 |
| TOP1 |
0083 |
topoisomerase (DNA) I |
DNA condensation |
9 |
5 |
| TOP2A |
0080 |
topoisomerase (DNA) II alpha 170kDa |
DNA condensation, growth and development |
8 |
6 |
| TOP2B |
0081 |
topoisomerase (DNA) II beta 180kDa |
DNA condensation, growth and development |
8 |
4 |
| TOP3B |
0148 |
topoisomerase (DNA) III beta |
DNA repair, DNA condensation |
7 |
0 |
| TP53 |
0006 |
tumor protein p53 |
DNA repair, apoptosis, stress response, cell cycle control |
130 |
59 |
| TP63 |
0234 |
tumor protein p63 |
apoptosis, stress response, cell cycle control |
9 |
1 |
| TXN |
0016 |
thioredoxin |
redox and oxidative regulation, transcriptional regulation |
13 |
3 |
| UBB |
0066 |
ubiquitin B |
DNA condensation, stress response, other |
8 |
1 |
| UBE2I |
0085 |
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) |
DNA repair, cell cycle control |
5 |
10 |
| UCHL1 |
0136 |
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
other |
6 |
1 |
| UCP1 |
0258 |
uncoupling protein 1 (mitochondrial, proton carrier) |
energy apparatus, redox and oxidative regulation |
5 |
0 |
| UCP2 |
0235 |
uncoupling protein 2 (mitochondrial, proton carrier) |
energy apparatus, redox and oxidative regulation |
19 |
1 |
| UCP3 |
0232 |
uncoupling protein 3 (mitochondrial, proton carrier) |
energy apparatus, redox and oxidative regulation |
19 |
1 |
| VCP |
0071 |
valosin-containing protein |
cell cycle control, other |
3 |
4 |
| VEGFA |
0077 |
vascular endothelial growth factor A |
apoptosis, growth and development |
15 |
2 |
| WRN |
0013 |
Werner syndrome, RecQ helicase-like |
DNA repair, DNA condensation |
84 |
20 |
| XPA |
0126 |
xeroderma pigmentosum, complementation group A |
DNA repair |
15 |
3 |
| XRCC5 |
0112 |
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |
DNA repair, DNA condensation |
22 |
6 |
| XRCC6 |
0117 |
X-ray repair complementing defective repair in Chinese hamster cells 6 |
DNA repair, DNA condensation, transcriptional regulation |
18 |
12 |
| YWHAZ |
0164 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide |
apoptosis, cell cycle control, signalling |
3 |
13 |
| ZMPSTE24 |
0233 |
zinc metallopeptidase (STE24 homolog, S. cerevisiae) |
other |
11 |
0 |