GenAge entry for HSPD1 (Homo sapiens)

Gene name (HAGRID: 159)

HGNC symbol
HSPD1 
Aliases
GroEL; HSP60; SPG13 
Common name
heat shock 60kDa protein 1 (chaperonin) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

HSPD1 plays a role in stress response in the mitochondria [753]. Heat-shock proteins have been suggested as a player in the ageing of model organisms such as invertebrates. Age-related changes in heat-shock proteins, including HSPD1, have also been reported in rats [1644]. A mutation in the human HSPD1 gene has been associated with spastic paraplegia [1713]. HSPD1's relevance to human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
2q33.1
Location
197,486,584 bp to 197,499,916 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002368; B cell cytokine production
GO:0002755; MyD88-dependent toll-like receptor signaling pathway
GO:0002842; positive regulation of T cell mediated immune response to tumor cell
GO:0006200; ATP catabolic process
GO:0006458; 'de novo' protein folding
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986; response to unfolded protein
GO:0019048; modulation by virus of host morphology or physiology
GO:0032727; positive regulation of interferon-alpha production
GO:0032729; positive regulation of interferon-gamma production
GO:0032733; positive regulation of interleukin-10 production
And 15 more GO terms
Cellular component: GO:0005615; extracellular space
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005759; mitochondrial matrix
GO:0005769; early endosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005905; coated pit
GO:0009986; cell surface
GO:0019907; cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135; coated vesicle
And 3 more GO terms
Function: GO:0001530; lipopolysaccharide binding
GO:0002039; p53 binding
GO:0003688; DNA replication origin binding
GO:0003697; single-stranded DNA binding
GO:0003725; double-stranded RNA binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0051082; unfolded protein binding
GO:0051087; chaperone binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
NR3C1, BAK1
STRING interaction network
Protein-Protein network diagram for HSPD1

Retrieve sequences for HSPD1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsp-60
Drosophila melanogaster
Hsp60C
Danio rerio
hspd1
Mus musculus
Hspd1
Rattus norvegicus
Hspd1
Saccharomyces cerevisiae
HSP60
Schizosaccharomyces pombe
hsp60

Selected references

External links

EPD
HS_HSPD1
ORF Accession
NM_002156
CDS Accession
NP_002147
OMIM
118190
HPRD
00318
Ensembl
HSPD1
UniProt/Swiss-Prot
CH60_HUMAN
GeneCards
HSPD1
Entrez Gene
3329
UniGene
595053
GenAtlas
HSPD1
Internet
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