GenAge entry for TRAP1 (Homo sapiens)

Gene name (HAGRID: 305)

HGNC symbol
TRAP1 
Aliases
HSP75; HSP90L 
Common name
TNF receptor-associated protein 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

TNFR-associated protein-1 (TRAP1) encodes a mitochondrial chaperone protein that is a member of the HSP90 family, and is thought to protect against oxidative stress and apoptosis. Knockout (-/-) of TRAP1 in mice produces viable mutants, with a reduced incidence of age-associated pathologies, including obesity, inflammatory tissue degeneration, dysplasia, and spontaneous tumour formation [3656].

Cytogenetic information

Cytogenetic band
16p13.3
Location
3,658,037 bp to 3,717,597 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006950; response to stress
GO:0009386; translational attenuation
GO:0061077; chaperone-mediated protein folding
GO:1901856; negative regulation of cellular respiration
GO:1903427; negative regulation of reactive oxygen species biosynthetic process
GO:1903751; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Cellular component: GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005758; mitochondrial intermembrane space
GO:0005759; mitochondrial matrix
GO:0005811; lipid particle
GO:0016020; membrane
GO:0070062; extracellular exosome
Function: GO:0005164; tumor necrosis factor receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019901; protein kinase binding
GO:0044822; poly(A) RNA binding
GO:0051082; unfolded protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
RB1, SOD1, APP, PCMT1, EEF1A1, H2AFX
STRING interaction network
Protein-Protein network diagram for TRAP1

Retrieve sequences for TRAP1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
CELE_R151.7
Danio rerio
trap1
Drosophila melanogaster
Trap1
Mus musculus
Trap1
Rattus norvegicus
Trap1

Selected references

External links

EPD
HS_TRAP1
ORF Accession
NM_016292
CDS Accession
NP_057376
OMIM
606219
HPRD
05868
Ensembl
TRAP1
UniProt/Swiss-Prot
Q53FS6_HUMAN
GeneCards
TRAP1
Entrez Gene
10131
UniGene
30345
GenAtlas
TRAP1
Internet
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