GenAge entry for PPARA (Homo sapiens)

Gene name (HAGRID: 55)

HGNC symbol
PPARA 
Aliases
hPPAR; NR1C1; PPAR 
Common name
peroxisome proliferator-activated receptor alpha 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

PPARA is a transcription factor that may be involved in the metabolic control of the expression of genes encoding fatty acid oxidation enzymes. Knockout mice have been reported to be protected from insulin (INS) resistance induced by high-fat diet [1928]. Certain age-related pathologies, such as heart disease, may be related to PPARA [392], but it unclear whether PPARA is a major player in human ageing.

Cytogenetic information

Cytogenetic band
22q13.31
Location
46,150,596 bp to 46,243,756 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001666; response to hypoxia
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006629; lipid metabolic process
GO:0006631; fatty acid metabolic process
GO:0007507; heart development
GO:0008544; epidermis development
GO:0010745; negative regulation of macrophage derived foam cell differentiation
GO:0010871; negative regulation of receptor biosynthetic process
GO:0010887; negative regulation of cholesterol storage
GO:0010891; negative regulation of sequestering of triglyceride
And 29 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001223; transcription coactivator binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003707; steroid hormone receptor activity
GO:0004879; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005515; protein binding
And 12 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POU1F1, NCOR1, BCL2, HSP90AA1, UBE2I, EP300, GRB2, RELA, SIRT1, PPARGC1A, NCOR2
STRING interaction network
Protein-Protein network diagram for PPARA

Retrieve sequences for PPARA

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
LOC100534818
Mus musculus
Ppara
Rattus norvegicus
Ppara

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Ppara
LongevityMap
  • This gene is present as PPARA

Selected references

External links

EPD
ORF Accession
NM_005036
CDS Accession
NP_005027
OMIM
170998
HPRD
01369
Ensembl
PPARA
UniProt/Swiss-Prot
PPARA_HUMAN
GeneCards
PPARA
Entrez Gene
5465
UniGene
103110
GenAtlas
PPARA
Internet
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