GenAge entry for UCP2 (Homo sapiens)

Gene name (HAGRID: 235)

HGNC symbol
UCP2 
Aliases
SLC25A8; BMIQ4 
Common name
uncoupling protein 2 (mitochondrial, proton carrier) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. Like similar proteins, UCP2 appears thus to be involved in thermogenesis.

In the fruit fly, overexpression of human UCP2 in adult neurons decreases oxidative damage and extends lifespan [1496]. Transgenic mice overexpressing UCP2 in hypocretin neurons have an elevated hypothalamic temperature which results in reduction of the core body temperature. These animals had increased energy efficiency and an extended lifespan [1932]. UCP2-null mice have a significantly shorter lifespan as a result of an accelerated aging process [1505]. The mice reach sexual maturity earlier and progress into an aging phenotype earlier, demonstrated by a decrease in body weight, increased neutrophil numbers, and earlier emergence of spontaneous ulcerative dermatitis. This accelerated aging seems to be driven by increased levels of circulating IGF1, indicating potential crosstalk between UPC2 and the INS/IFG1 signalling pathway [4350]. In addition, UCP2-null mice have been shown to have increased glucose-stimulated INS secretion [1505]. In humans, UCP2 polymorphisms have been linked to obesity and are associated with longevity [1503].

Cytogenetic information

Cytogenetic band
11q13
Location
73,974,671 bp to 73,982,844 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000303; response to superoxide
GO:0001666; response to hypoxia
GO:0006810; transport
GO:0006839; mitochondrial transport
GO:0007565; female pregnancy
GO:0007568; aging
GO:0010942; positive regulation of cell death
GO:0015992; proton transport
GO:0032869; cellular response to insulin stimulus
GO:0034198; cellular response to amino acid starvation
GO:0043066; negative regulation of apoptotic process
And 6 more GO terms
Cellular component: GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane
Function: GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
YWHAZ
STRING interaction network
Protein-Protein network diagram for UCP2

Retrieve sequences for UCP2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ucp2
Mus musculus
Ucp2
Rattus norvegicus
Ucp2

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as UCP2
  • A homolog of this gene for Mus musculus is present as Ucp2
LongevityMap
  • This gene is present as UCP2

Selected references

External links

EPD
HS_UCP2
ORF Accession
NM_003355
CDS Accession
NP_003346
OMIM
601693
HPRD
03410
Ensembl
UCP2
UniProt/Swiss-Prot
UCP2_HUMAN
GeneCards
UCP2
Entrez Gene
7351
UniGene
80658
GenAtlas
UCP2
Internet
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