GenAge entry for IL2 (Homo sapiens)

Gene name (HAGRID: 46)

HGNC symbol
IL2 
Aliases
IL-2; TCGF 
Common name
interleukin 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

IL2 is a cytokine that has been associated with age-related changes at the immune system level [369]. Studies of polymorphisms in the human IL2 gene, however, have so far failed to find an association with human longevity [222].

Cytogenetic information

Cytogenetic band
4q26-q27
Location
122,451,471 bp to 122,456,495 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001933; negative regulation of protein phosphorylation
GO:0002903; negative regulation of B cell apoptotic process
GO:0006955; immune response
GO:0007155; cell adhesion
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007205; protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0030101; natural killer cell activation
GO:0030217; T cell differentiation
GO:0030307; positive regulation of cell growth
And 18 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
Function: GO:0005125; cytokine activity
GO:0005134; interleukin-2 receptor binding
GO:0008083; growth factor activity
GO:0019209; kinase activator activity
GO:0030246; carbohydrate binding
GO:0031851; kappa-type opioid receptor binding
GO:0043208; glycosphingolipid binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, IL2RG
STRING interaction network
Protein-Protein network diagram for IL2

Retrieve sequences for IL2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Il2
Rattus norvegicus
Il2

In other databases

LongevityMap
  • This gene is present as IL2

Selected references

External links

EPD
HS_IL2
ORF Accession
NM_000586
CDS Accession
NP_000577
OMIM
147680
HPRD
00979
Ensembl
IL2
UniProt/Swiss-Prot
IL2_HUMAN
GeneCards
IL2
Entrez Gene
3558
UniGene
89679
GenAtlas
IL2
Internet
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