GenAge entry for PTEN (Homo sapiens)

Gene name (HAGRID: 63)

HGNC symbol
PTEN 
Aliases
MMAC1; TEP1; PTEN1; BZS; MHAM 
Common name
phosphatase and tensin homolog 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

PTEN is a tumour suppressor involved in cell cycle progression as an inhibitor of insulin (INS) signalling. In roundworms, a PTEN homologue has been related to development and longevity regulation through the INS-like pathway [1348]. The same gene has been shown to mediate nutrient-dependent cell cycle arrest and growth in the germline of roundworms [1771]. PTEN-null mice die at embryonic stages while heterozygous animals develop tumours [1757]. In mice lacking PTEN in oocytes the entire primordial follicle pool becomes activated and thus all primordial follicles become depleted in early adulthood causing premature ovarian failure [1905]. Mice carrying additional copies of PTEN are protected from cancer and present a modest (16%) extension of life span that is independent of their lower cancer incidence [2457]. Mutations in the human PTEN gene have been associated with cancer [1577], and further studies are necessary to determine whether PTEN plays a role in human ageing.

Cytogenetic information

Cytogenetic band
10q23.3
Location
87,863,438 bp to 87,971,930 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001525; angiogenesis
GO:0001933; negative regulation of protein phosphorylation
GO:0002902; regulation of B cell apoptotic process
GO:0006470; protein dephosphorylation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0006915; apoptotic process
GO:0007270; neuron-neuron synaptic transmission
GO:0007416; synapse assembly
GO:0007417; central nervous system development
GO:0007507; heart development
And 82 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0009898; cytoplasmic side of plasma membrane
GO:0016324; apical plasma membrane
GO:0016605; PML body
GO:0035749; myelin sheath adaxonal region
And 6 more GO terms
Function: GO:0000287; magnesium ion binding
GO:0004438; phosphatidylinositol-3-phosphatase activity
GO:0004721; phosphoprotein phosphatase activity
GO:0004722; protein serine/threonine phosphatase activity
GO:0004725; protein tyrosine phosphatase activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005515; protein binding
GO:0008138; protein tyrosine/serine/threonine phosphatase activity
GO:0008289; lipid binding
GO:0010997; anaphase-promoting complex binding
GO:0016314; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TXN, AKT1, PDGFRB, HSP90AA1, EGR1, UBE2I, EEF2, AR, PRDX1, HSPD1, HSPA1A, PTK2B, PTK2, BMI1, HSPA8, MXD1, ESR1, CTNNB1, PPP1CA, DBN1, STUB1, PDGFRA
STRING interaction network
Protein-Protein network diagram for PTEN

Retrieve sequences for PTEN

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ptena
Drosophila melanogaster
Pten
Mus musculus
Pten
Rattus norvegicus
Pten

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Pten
  • A homolog of this gene for Mus musculus is present as Pten

Selected references

External links

EPD
ORF Accession
NM_000314
CDS Accession
NP_000305
OMIM
601728
HPRD
03431
Ensembl
PTEN
UniProt/Swiss-Prot
PTEN_HUMAN
GeneCards
PTEN
Entrez Gene
5728
UniGene
500466
GenAtlas
PTEN
Internet
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