GenAge entry for MXI1 (Homo sapiens)

Gene name (HAGRID: 90)

HGNC symbol
MXI1 
Aliases
MXD2; MAD2; MXI; bHLHc11 
Common name
MAX interactor 1, dimerization protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

MXI1 is an antagonist of MYC in that it competes with MYC for MAX [945]. Mice lacking MXI1 exhibit progressive, multisystem abnormalities and increased susceptibility to tumorigenesis. A role for MXI1 in murine ageing has thus been suggested [887]. Mutations in the human MXI1 gene have been linked to cancer [944]. Additional, more detailed, studies are necessary to determine whether MXI1 is related to human ageing.

Cytogenetic information

Cytogenetic band
10q24-q25
Location
110,226,004 bp to 110,287,365 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0008285; negative regulation of cell proliferation
GO:0042994; cytoplasmic sequestering of transcription factor
GO:1903507; negative regulation of nucleic acid-templated transcription
Cellular component: GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
Function: GO:0003677; DNA binding
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0046983; protein dimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
APP, BUB1B, MAX
STRING interaction network
Protein-Protein network diagram for MXI1

Retrieve sequences for MXI1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
mxi1
Mus musculus
Mxi1
Rattus norvegicus
Mxi1

Selected references

External links

EPD
ORF Accession
NM_005962
CDS Accession
NP_005953
OMIM
600020
HPRD
02486
Ensembl
MXI1
UniProt/Swiss-Prot
MXI1_HUMAN
GeneCards
MXI1
Entrez Gene
4601
UniGene
501023
GenAtlas
MXI1
Internet
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