GenAge entry for UCP1 (Homo sapiens)

Gene name (HAGRID: 258)

HGNC symbol
UCP1 
Aliases
SLC25A7; UCP 
Common name
uncoupling protein 1 (mitochondrial, proton carrier) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. Mice with skeletal muscle-specific UCP1 expression had increased median survival, decreased adiposity, increased temperature and metabolic rate. The same genetic manipulation in APOE null mice decreased diet-induced atherosclerosis and in agouti yellow mice, a model of obesity, diabetes and hypertension were reversed [1850].

Cytogenetic information

Cytogenetic band
4q28-q31
Location
140,559,896 bp to 140,568,805 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006839; mitochondrial transport
GO:0015992; proton transport
GO:0022904; respiratory electron transport chain
GO:0044237; cellular metabolic process
GO:0044281; small molecule metabolic process
GO:0050873; brown fat cell differentiation
Cellular component: GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral to membrane
Function: GO:0017077; oxidative phosphorylation uncoupler activity
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for UCP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Ucp1
Rattus norvegicus
Ucp1

In other databases

LongevityMap
  • This gene is present as UCP1

Selected references

External links

EPD
ORF Accession
NM_021833
CDS Accession
NP_068605
OMIM
113730
HPRD
00221
Ensembl
UCP1
UniProt/Swiss-Prot
UCP1_HUMAN
GeneCards
UCP1
Entrez Gene
7350
UniGene
249211
GenAtlas
UCP1
Internet
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