GenAge entry for NFE2L1 (Homo sapiens)

Gene name (HAGRID: 307)

HGNC symbol
NFE2L1 
Aliases
NRF1; LCR-F1; FLJ00380; TCF11 
Common name
nuclear factor, erythroid 2-like 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

The Nuclear Factor, Erythroid 2-Like 1 (NFE2L1), is involved in globin gene expression in erythrocytes. Overexpressing SKN-1, one of its ortholog genes, in worms has been reported to mildly extend lifespan (by 5-20%) [2497]. Contrastly, RNA interference in SKN-1 prevents the life-extension effects of caloric restriction [2360] and it was shown that SKN-1 is involved in the insulin/IGF-1 signaling, being necessary for the DAF-16/DAF-2 lifespan extension pathway [3650].

Cytogenetic information

Cytogenetic band
17q21.3
Location
48,048,324 bp to 48,061,545 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006783; heme biosynthetic process
GO:0006954; inflammatory response
GO:0009653; anatomical structure morphogenesis
GO:0030218; erythrocyte differentiation
GO:0034599; cellular response to oxidative stress
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005789; endoplasmic reticulum membrane
GO:0016021; integral component of membrane
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003712; transcription cofactor activity
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GSK3B, JUN, NFE2L1
STRING interaction network
Protein-Protein network diagram for NFE2L1

Retrieve sequences for NFE2L1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
LOC558772
Mus musculus
Nfe2l1

Selected references

External links

EPD
ORF Accession
NM_003204
CDS Accession
NP_003195
OMIM
163260
HPRD
01223
Ensembl
NFE2L1
UniProt/Swiss-Prot
J9JIE5_HUMAN
GeneCards
NFE2L1
Entrez Gene
4779
UniGene
514284
GenAtlas
NFE2L1
Internet
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