GenAge entry for SNCG (Homo sapiens)

Gene name (HAGRID: 140)

HGNC symbol
SNCG 
Aliases
BCSG1; SR; persyn 
Common name
synuclein, gamma (breast cancer-specific protein 1) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

SNCG is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. SNCG also appears to regulate BUB1B [1702]. While SNCG has been linked to cancer and CNS development [1083], its role, if any, in human ageing is unknown.

Cytogenetic information

Cytogenetic band
10q23.2-q2
Location
86,958,531 bp to 86,963,260 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002118; aggressive behavior
GO:0007268; synaptic transmission
GO:0008344; adult locomotory behavior
GO:0014059; regulation of dopamine secretion
GO:0042220; response to cocaine
GO:0042493; response to drug
GO:0046928; regulation of neurotransmitter secretion
GO:0050808; synapse organization
GO:0071464; cellular response to hydrostatic pressure
Cellular component: GO:0005815; microtubule organizing center
GO:0005819; spindle
GO:0005886; plasma membrane
GO:0043025; neuronal cell body
GO:0043679; axon terminus
GO:0048471; perinuclear region of cytoplasm
Function: GO:0043014; alpha-tubulin binding
GO:0048487; beta-tubulin binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
MAPK8, MAPK3, BUB1B
STRING interaction network
Protein-Protein network diagram for SNCG

Retrieve sequences for SNCG

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
sncgb
Mus musculus
Sncg
Rattus norvegicus
Sncg

Selected references

External links

EPD
ORF Accession
NM_003087
CDS Accession
NP_003078
OMIM
602998
HPRD
04297
Ensembl
SNCG
UniProt/Swiss-Prot
SYUG_HUMAN
GeneCards
SNCG
Entrez Gene
6623
UniGene
349470
GenAtlas
SNCG
Internet
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