GenAge entry for JAK2 (Homo sapiens)

Gene name (HAGRID: 215)

HGNC symbol
JAK2 
Aliases
JTK10 
Common name
Janus kinase 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

JAK2 is a tyrosine kinase involved in cytokine receptor signalling. Disruption of JAK2 causes embryonic lethality due to the absence of definitive erythropoiesis [1175], however, knockdown or pharmacological inhibition of the JAK-STAT enhances satellite stem cell division potential resulting in better muscle regeneration [3635]. Its signalling functions and its association with a number of genes previously linked to ageing suggest JAK2 may play some role in ageing, even though a direct association of JAK2 with human ageing has not been established.

Cytogenetic information

Cytogenetic band
9p24
Location
4,985,245 bp to 5,128,183 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000186; activation of MAPKK activity
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006928; cellular component movement
GO:0007165; signal transduction
GO:0007167; enzyme linked receptor protein signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007259; JAK-STAT cascade
GO:0007260; tyrosine phosphorylation of STAT protein
And 62 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0005901; caveola
GO:0012505; endomembrane system
GO:0016363; nuclear matrix
GO:0031904; endosome lumen
GO:0045121; membrane raft
Function: GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005102; receptor binding
GO:0005131; growth hormone receptor binding
GO:0005143; interleukin-12 receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0019901; protein kinase binding
GO:0020037; heme binding
And 9 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, SHC1, STAT3, STAT5A, ERBB2, EPOR, BRCA1, VCP, GRB2, PTK2, PIK3R1, HSPA8, LEPR
STRING interaction network
Protein-Protein network diagram for JAK2

Retrieve sequences for JAK2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
jak2b
Mus musculus
Jak2
Rattus norvegicus
Jak2

In other databases

LongevityMap
  • This gene is present as JAK2

Selected references

External links

EPD
ORF Accession
NM_004972
CDS Accession
NP_004963
OMIM
147796
HPRD
00993
Ensembl
JAK2
UniProt/Swiss-Prot
JAK2_HUMAN
GeneCards
JAK2
Entrez Gene
3717
UniGene
656213
GenAtlas
JAK2
Internet
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