GenAge entry for IGF2 (Homo sapiens)

Gene name (HAGRID: 29)

HGNC symbol
IGF2 
Aliases
FLJ44734; IGF-II; C11orf43 
Common name
insulin-like growth factor 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Like IGF1, IGF2 is involved in growth and development. Unlike IGF1, IGF2 appears to be only active at early stages of development, such as embryonic growth. IGF2's role in ageing is unproven and its interest derives mostly from its connection with IGF1 and how the IGF1/GH1 axis appears to regulate ageing in model organisms [425]. Mice with disrupted IGF2 are growth-deficient but their lifespan has not been studied [1309]. Polymorphisms in the human IGF2 gene have been associated with body mass index in adult males [1656].

Cytogenetic information

Cytogenetic band
11p15.5
Location
2,129,112 bp to 2,138,974 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001501; skeletal system development
GO:0001503; ossification
GO:0001934; positive regulation of protein phosphorylation
GO:0002576; platelet degranulation
GO:0006006; glucose metabolic process
GO:0006349; regulation of gene expression by genetic imprinting
GO:0006355; regulation of transcription, DNA-dependent
GO:0007275; multicellular organismal development
GO:0007596; blood coagulation
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
And 16 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0031093; platelet alpha granule lumen
Function: GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005179; hormone activity
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0030546; receptor activator activity
GO:0043539; protein serine/threonine kinase activator activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IGF1R, INSR
STRING interaction network
Protein-Protein network diagram for IGF2

Retrieve sequences for IGF2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
igf2a
Mus musculus
Igf2
Rattus norvegicus
Igf2

In other databases

LongevityMap
  • This gene is present as IGF2

Selected references

External links

EPD
HS_IGF2_4
ORF Accession
NM_000612
CDS Accession
NP_000603
OMIM
147470
HPRD
00939
Ensembl
IGF2
UniProt/Swiss-Prot
IGF2_HUMAN
GeneCards
IGF2
Entrez Gene
3481
UniGene
523414
GenAtlas
IGF2
Internet
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