GenAge entry for PDGFB (Homo sapiens)

Gene name (HAGRID: 47)

HGNC symbol
PDGFB 
Aliases
SSV; SIS 
Common name
platelet-derived growth factor beta polypeptide 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

PDGFB is a mitogen and oncogene involved in cell survival, development, and healing [363]. Results from rats suggest it may be related to age-related changes in the heart [362], and PDGF's anti-apoptotic signalling involves several pathways and genes that in turn have been associated with ageing [333]. PDGFB's exact relevance to human ageing, however, is unknown.

Cytogenetic information

Cytogenetic band
22q13.1
Location
39,223,680 bp to 39,244,952 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0001892; embryonic placenta development
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002548; monocyte chemotaxis
GO:0002576; platelet degranulation
GO:0003104; positive regulation of glomerular filtration
GO:0006468; protein phosphorylation
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007507; heart development
GO:0008284; positive regulation of cell proliferation
GO:0009611; response to wounding
And 59 more GO terms
Cellular component: GO:0000139; Golgi membrane
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0005788; endoplasmic reticulum lumen
GO:0009986; cell surface
GO:0016323; basolateral plasma membrane
GO:0031012; extracellular matrix
GO:0031093; platelet alpha granule lumen
Function: GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005515; protein binding
GO:0005518; collagen binding
GO:0008083; growth factor activity
GO:0016176; superoxide-generating NADPH oxidase activator activity
GO:0042056; chemoattractant activity
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982; protein heterodimerization activity
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PDGFB, PDGFRB, PDGFRA
STRING interaction network
Protein-Protein network diagram for PDGFB

Retrieve sequences for PDGFB

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Pdgfb
Rattus norvegicus
Pdgfb

Selected references

External links

EPD
HS_PDGFB
ORF Accession
NM_002608
CDS Accession
NP_002599
OMIM
190040
HPRD
01815
Ensembl
PDGFB
UniProt/Swiss-Prot
PDGFB_HUMAN
GeneCards
PDGFB
Entrez Gene
5155
UniGene
1976
GenAtlas
PDGFB
Internet
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