GenAge entry for HSP90AA1 (Homo sapiens)

Gene name (HAGRID: 74)

HGNC symbol
HSP90AA1 
Aliases
Hsp89; Hsp90; FLJ31884; HSP90N; HSPC1; HSPCA 
Common name
heat shock protein 90kDa alpha (cytosolic), class A member 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Also known as Hsp90, HSP90AA1 is a molecular chaperone. Similar proteins have been suggested to impact on the ageing process of model organisms [632]. HSP90AA1 is affected by ageing in rats [909], though no evidence has directly linked HSP90AA1 to human ageing.

Cytogenetic information

Cytogenetic band
14q32.33
Location
102,080,738 bp to 102,087,175 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0000278; mitotic cell cycle
GO:0001764; neuron migration
GO:0003009; skeletal muscle contraction
GO:0006200; ATP catabolic process
GO:0006839; mitochondrial transport
GO:0006986; response to unfolded protein
GO:0007165; signal transduction
GO:0007411; axon guidance
GO:0009408; response to heat
GO:0009651; response to salt stress
And 16 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0009986; cell surface
GO:0016323; basolateral plasma membrane
GO:0016324; apical plasma membrane
GO:0031012; extracellular matrix
GO:0031526; brush border membrane
GO:0042470; melanosome
GO:0043005; neuron projection
GO:0043025; neuronal cell body
And 4 more GO terms
Function: GO:0000166; nucleotide binding
GO:0002134; UTP binding
GO:0002135; CTP binding
GO:0003729; mRNA binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0005525; GTP binding
GO:0016887; ATPase activity
GO:0017098; sulfonylurea receptor binding
GO:0019901; protein kinase binding
GO:0019903; protein phosphatase binding
And 8 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERT, STAT3, AKT1, MYC, PPARA, HIF1A, NR3C1, PDPK1, AR, HSF1, HSPA1A, HSPA8, ESR1, ARNTL
STRING interaction network
Protein-Protein network diagram for HSP90AA1

Retrieve sequences for HSP90AA1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
daf-21
Danio rerio
hsp90aa1.2
Mus musculus
Hsp90aa1
Rattus norvegicus
Hsp90aa1

Selected references

External links

EPD
HS_HSPCA
ORF Accession
NM_005348
CDS Accession
NP_005339
OMIM
140571
HPRD
00777
Ensembl
HSP90AA1
UniProt/Swiss-Prot
HS90A_HUMAN
GeneCards
HSP90AA1
Entrez Gene
3320
UniGene
523560
GenAtlas
HSP90AA1
Internet
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