GenAge entry for HSP90AA1 (Homo sapiens)

Gene name (HAGRID: 74)

HGNC symbol
HSP90AA1 
Aliases
Hsp89; Hsp90; FLJ31884; HSP90N; HSPC1; HSPCA 
Common name
heat shock protein 90kDa alpha (cytosolic), class A member 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Also known as Hsp90, HSP90AA1 is a molecular chaperone. Similar proteins have been suggested to impact on the ageing process of model organisms [632]. HSP90AA1 is affected by ageing in rats [909], though no evidence has directly linked HSP90AA1 to human ageing.

Cytogenetic information

Cytogenetic band
14q32.33
Location
102,080,738 bp to 102,087,175 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0006839; mitochondrial transport
GO:0006898; receptor-mediated endocytosis
GO:0006986; response to unfolded protein
GO:0007165; signal transduction
GO:0009408; response to heat
GO:0009409; response to cold
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0031396; regulation of protein ubiquitination
GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128; ERBB2 signaling pathway
And 13 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0032587; ruffle membrane
GO:0042470; melanosome
GO:0043202; lysosomal lumen
GO:0043209; myelin sheath
And 3 more GO terms
Function: GO:0000166; nucleotide binding
GO:0004713; protein tyrosine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0023026; MHC class II protein complex binding
GO:0030235; nitric-oxide synthase regulator activity
GO:0030911; TPR domain binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0042826; histone deacetylase binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, TERT, IGF1R, STAT3, AKT1, MYC, EGFR, ERBB2, PDGFRB, PRKCD, PPARA, RET, BRCA1, PTEN, HIF1A, BLM, BCL2, HSP90AA1, VEGFA, ABL1, RAD51, STK11, GSK3B, PRKCA, EEF2, TERF1, PRKDC, AR, TERF2, HSPA8, GRB2, HSF1, FOXM1, UCHL1, APP, RAD52, SIRT1, HSPA1A, HSPA1B, PTK2B, PTK2, FGFR1, SP1, JUN, MAP3K5, EEF1A1, ATF2, JAK2, HSPA9, SIN3A, CDK1, MAX, MDM2, VCP, H2AFX, NR3C1, ESR1, CDKN2A, ATR, STUB1, ARNTL, CDKN1A, MIF, GSK3A, IKBKB, CDK7
STRING interaction network
Protein-Protein network diagram for HSP90AA1

Retrieve sequences for HSP90AA1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
daf-21
Danio rerio
hsp90aa1.2
Mus musculus
Hsp90aa1
Rattus norvegicus
Hsp90aa1

Selected references

External links

EPD
HS_HSPCA
ORF Accession
NM_005348
CDS Accession
NP_005339
OMIM
140571
HPRD
00777
Ensembl
HSP90AA1
UniProt/Swiss-Prot
HS90A_HUMAN
GeneCards
HSP90AA1
Entrez Gene
3320
UniGene
523560
GenAtlas
HSP90AA1
Internet
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