GenAge entry for JUN (Homo sapiens)

Gene name (HAGRID: 172)

HGNC symbol
JUN 
Aliases
c-Jun; AP-1 
Common name
jun proto-oncogene 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

JUN is an important transcription factor that is also a member of the AP-1 transcriptional complex. Its signalling pathway has been related to ageing in fruit flies [212] and roundworms [60], though a direct role of JUN has not been demonstrated. Results from mice have shown that AP-1's DNA-binding activity decreases with age [837]. JUN-null mice die at embryonic stages [783]. Further research is needed to assess JUN'1 role in human ageing.

Cytogenetic information

Cytogenetic band
1p32-p31
Location
58,780,791 bp to 58,784,113 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001525; angiogenesis
GO:0001774; microglial cell activation
GO:0001836; release of cytochrome c from mitochondria
GO:0001889; liver development
GO:0001938; positive regulation of endothelial cell proliferation
GO:0003151; outflow tract morphogenesis
GO:0006366; transcription from RNA polymerase II promoter
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007184; SMAD protein import into nucleus
GO:0007265; Ras protein signal transduction
GO:0007568; aging
And 46 more GO terms
Cellular component: GO:0000228; nuclear chromosome
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005719; nuclear euchromatin
GO:0005829; cytosol
GO:0017053; transcriptional repressor complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
And 14 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POU1F1, STAT3, MYC, FOS, HDAC3, PARP1, BRCA1, PIN1, CREBBP, HIF1A, NCOR1, HSP90AA1, ABL1, TOP2A, UBE2I, EP300, PML, GSK3B, PRKDC, AR, HSPA8, RB1, APP, SIRT1, HDAC1, MAPK8, MAPK14, SP1, JUN, MAPK9, MAPK3, TFAP2A, CREB1, ATF2, TBP, MDM2, TAF1, DDIT3, RELA, JUND, SUMO1, NR3C1, CEBPA, CEBPB, ESR1, PPARG, NCOR2, NFE2L2, CDKN1A, IKBKB, NFE2L1
STRING interaction network
Protein-Protein network diagram for JUN

Retrieve sequences for JUN

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
jun
Mus musculus
Jun
Rattus norvegicus
Jun

Selected references

External links

EPD
HS_JUN
ORF Accession
NM_002228
CDS Accession
NP_002219
OMIM
165160
HPRD
01302
Ensembl
JUN
UniProt/Swiss-Prot
JUN_HUMAN
GeneCards
JUN
Entrez Gene
3725
UniGene
525704
GenAtlas
JUN
Internet
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