GenAge entry for NFKB2 (Homo sapiens)

Gene name (HAGRID: 20)

HGNC symbol
NFKB2 
Aliases
LYT-10; p52; p105; NF-kB2 
Common name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

NFKB2 is a component of the NF-kappa-B complex, involved in oxidative pathways and a myriad of other processes. Its role in ageing is unclear, even though NFKB2 appears to be related to age-related changes in inflammation and maybe in other age-related processes too [260]. In addition, age-relation changes in NF-kappa-B have been reported for numerous tissues [261].

Cytogenetic information

Cytogenetic band
10q24
Location
102,395,596 bp to 102,402,529 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002268; follicular dendritic cell differentiation
GO:0002467; germinal center formation
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006954; inflammatory response
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0007568; aging
GO:0030198; extracellular matrix organization
GO:0032481; positive regulation of type I interferon production
GO:0032496; response to lipopolysaccharide
And 8 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0033257; Bcl3/NF-kappaB2 complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
NFKB2, STAT3, VCP, NR3C1, NFKB1, RELA, SP1, NFKBIA, EPS8
STRING interaction network
Protein-Protein network diagram for NFKB2

Retrieve sequences for NFKB2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
nfkb2
Mus musculus
Nfkb2
Rattus norvegicus
Nfkb2

Selected references

External links

EPD
ORF Accession
NM_002502
CDS Accession
NP_002493
OMIM
164012
HPRD
01239
Ensembl
NFKB2
UniProt/Swiss-Prot
NFKB2_HUMAN
GeneCards
NFKB2
Entrez Gene
4791
UniGene
73090
GenAtlas
NFKB2
Internet
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