GenAge entry for POLA1 (Homo sapiens)

Gene name (HAGRID: 204)

HGNC symbol
POLA1 
Aliases
p180; POLA; NSX 
Common name
polymerase (DNA directed), alpha 1, catalytic subunit 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

POLA1 is involved in DNA replication. In yeast, mutations in POLA1 reduce lifespan [1425]. Age-related changes in POLA1 induction have been shown in rats [580]. Whether POLA1 is involved in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
Xp22.1-p21
Location
24,693,947 bp to 24,996,985 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000731; DNA synthesis involved in DNA repair
GO:0006260; DNA replication
GO:0006269; DNA replication, synthesis of RNA primer
GO:0006270; DNA replication initiation
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006272; leading strand elongation
GO:0006273; lagging strand elongation
GO:0006281; DNA repair
And 5 more GO terms
Cellular component: GO:0000785; chromatin
GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005658; alpha DNA polymerase:primase complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0016363; nuclear matrix
Function: GO:0000166; nucleotide binding
GO:0001882; nucleoside binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0003896; DNA primase activity
GO:0005515; protein binding
GO:0008408; 3'-5' exonuclease activity
GO:0019901; protein kinase binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, MYC, PARP1, RPA1, XRCC5, PCNA, RB1, CCNA2, CDK1, RAE1, SIRT7
STRING interaction network
Protein-Protein network diagram for POLA1

Retrieve sequences for POLA1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
CELE_Y47D3A.29
Danio rerio
pola1
Drosophila melanogaster
DNApol-alpha180
Mus musculus
Pola1
Rattus norvegicus
Pola1
Saccharomyces cerevisiae
POL1
Schizosaccharomyces pombe
pol1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as Y47D3A.29

Selected references

External links

EPD
ORF Accession
NM_016937
CDS Accession
NP_058633
OMIM
312040
HPRD
02416
Ensembl
POLA1
UniProt/Swiss-Prot
DPOLA_HUMAN
GeneCards
POLA1
Entrez Gene
5422
UniGene
567319
GenAtlas
POLA1
Internet
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