GenAge entry for TCF3 (Homo sapiens)

Gene name (HAGRID: 59)

HGNC symbol
TCF3 
Aliases
E2A; ITF1; MGC129647; MGC129648; bHLHb21; VDIR; E47 
Common name
transcription factor 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

A crucial protein in development, TCF3 may be involved in ageing of the immune system [1529].

Cytogenetic information

Cytogenetic band
19p13.3
Location
1,609,290 bp to 1,652,329 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002326; B cell lineage commitment
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0030183; B cell differentiation
GO:0033152; immunoglobulin V(D)J recombination
GO:0045666; positive regulation of neuron differentiation
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0051091; positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051149; positive regulation of muscle cell differentiation
And 1 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0090575; RNA polymerase II transcription factor complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0031435; mitogen-activated protein kinase kinase kinase binding
GO:0035326; enhancer binding
GO:0042803; protein homodimerization activity
GO:0043425; bHLH transcription factor binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TCF3, PARP1, CREBBP, UBE2I, EP300, RB1, HDAC2
STRING interaction network
Protein-Protein network diagram for TCF3

Retrieve sequences for TCF3

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
zgc:113045
Drosophila melanogaster
da
Mus musculus
Tcf3
Rattus norvegicus
Tcf3

Selected references

External links

EPD
ORF Accession
NM_003200
CDS Accession
NP_003191
OMIM
147141
HPRD
00918
Ensembl
TCF3
UniProt/Swiss-Prot
TFE2_HUMAN
GeneCards
TCF3
Entrez Gene
6929
UniGene
371282
GenAtlas
TCF3
Internet
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