GenAge entry for PPARGC1A (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 256)

HGNC symbol
PPARGC1A 
Aliases
PGC1; PGC1A; PPARGC1 
Common name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

PPARGC1A is a transcriptional coactivator that regulates and interacts with genes involved in energy metabolism [1847]. It has a role in regulating metabolism, inflammation, oxidative stress resistance and mitochondrial biogenesis and function [4340]. SIRT1 has been reported to be a functional regulator of PPARGC1A [1846].

In mice, knockout of PPARGC1A accelerates vascular aging and atherosclerosis, coinciding with telomere dysfunction and shortening and DNA damage. Expression of PPARGC1A coactivates TERT transcription and reverses telomere malfunction [4340]. In humans, PPARGC1A has been associated with cholesterol and obesity as well as age-related diseases like type 2 diabetes. Thus, PPARGC1A may play a role in in ameliorating senescence, aging, and age-associated chronic diseases.

Cytogenetic information

Cytogenetic band
4p15.1
Location
23,792,021 bp to 23,890,077 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0000422; mitophagy
GO:0001659; temperature homeostasis
GO:0001678; cellular glucose homeostasis
GO:0001933; negative regulation of protein phosphorylation
GO:0002021; response to dietary excess
GO:0002931; response to ischemia
GO:0006012; galactose metabolic process
GO:0006094; gluconeogenesis
GO:0006355; regulation of transcription, DNA-templated
GO:0006367; transcription initiation from RNA polymerase II promoter
And 72 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005665; DNA-directed RNA polymerase II, core complex
GO:0005719; nuclear euchromatin
GO:0016605; PML body
GO:0022626; cytosolic ribosome
GO:0043025; neuronal cell body
GO:0097440; apical dendrite
GO:1990843; subsarcolemmal mitochondrion
GO:1990844; interfibrillar mitochondrion
Function: GO:0000166; nucleotide binding
GO:0001104; RNA polymerase II transcription cofactor activity
GO:0003677; DNA binding
GO:0003713; transcription coactivator activity
GO:0003723; RNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0030331; estrogen receptor binding
GO:0030374; ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490; chromatin DNA binding
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, EGFR, PPARA, CREBBP, NR3C1, NFKB1, UBE2I, EP300, PML, GSK3B, RELA, SIRT1, MED1, ESR1, PPARG
STRING interaction network
Protein-Protein network diagram for PPARGC1A

Retrieve sequences for PPARGC1A

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ppargc1a
Mus musculus
Ppargc1a
Rattus norvegicus
Ppargc1a

In other databases

LongevityMap

Selected references

External links

EPD
ORF Accession
NM_013261
CDS Accession
NP_037393
OMIM
604517
HPRD
05155
Ensembl
PPARGC1A
UniProt/Swiss-Prot
PRGC1_HUMAN
GeneCards
PPARGC1A
Entrez Gene
10891
UniGene
527078
GenAtlas
PPARGC1A
Internet
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