GenAge entry for GSS (Homo sapiens)

Gene name (HAGRID: 155)

HGNC symbol
GSS 
Aliases
 
Common name
glutathione synthetase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

GSS is involved in redox regulation and oxidative defence. Mutations in the human GSS gene cause 5-oxoprolinuria [744]. There is no evidence directly linking GSS to ageing in humans or in model organisms.

Cytogenetic information

Cytogenetic band
20q11.2
Location
34,928,433 bp to 34,955,798 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006520; cellular amino acid metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006805; xenobiotic metabolic process
GO:0006979; response to oxidative stress
GO:0007399; nervous system development
GO:0007568; aging
GO:0031667; response to nutrient levels
GO:0034612; response to tumor necrosis factor
GO:0043200; response to amino acid
GO:0044281; small molecule metabolic process
GO:0046686; response to cadmium ion
And 2 more GO terms
Cellular component: GO:0005829; cytosol
Function: GO:0000287; magnesium ion binding
GO:0004363; glutathione synthase activity
GO:0005524; ATP binding
GO:0016594; glycine binding
GO:0042803; protein homodimerization activity
GO:0043295; glutathione binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for GSS

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
gss-1
Drosophila melanogaster
GS
Danio rerio
gss
Mus musculus
Gss
Rattus norvegicus
Gss
Saccharomyces cerevisiae
GSH2
Schizosaccharomyces pombe
gsa1

In other databases

LongevityMap
  • This gene is present as GSS

Selected references

External links

EPD
HS_GSS
ORF Accession
NM_000178
CDS Accession
NP_000169
OMIM
601002
HPRD
03000
Ensembl
GSS
UniProt/Swiss-Prot
GSHB_HUMAN
GeneCards
GSS
Entrez Gene
2937
UniGene
82327
GenAtlas
GSS
Internet
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