GenAge entry for HDAC2 (Homo sapiens)

Gene name (HAGRID: 207)

HGNC symbol
HDAC2 
Aliases
RPD3; YAF1 
Common name
histone deacetylase 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

HDAC2 performs the deacetylation of histones and is an important player in may processes such as development, transcriptional regulation, and cell cycle progression [736]. Homologues of HDAC2 have been linked to longevity in yeast [203] and to ageing and caloric restriction in fruit flies [202]. Whether HDAC2 is involved in human ageing, however, is not known.

Cytogenetic information

Cytogenetic band
6q21
Location
113,936,156 bp to 113,971,195 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006338; chromatin remodeling
GO:0006344; maintenance of chromatin silencing
GO:0006351; transcription, DNA-templated
GO:0007596; blood coagulation
GO:0008284; positive regulation of cell proliferation
GO:0009913; epidermal cell differentiation
GO:0010870; positive regulation of receptor biosynthetic process
GO:0010977; negative regulation of neuron projection development
GO:0016358; dendrite development
GO:0016575; histone deacetylation
And 25 more GO terms
Cellular component: GO:0000792; heterochromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005657; replication fork
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0016580; Sin3 complex
GO:0016581; NuRD complex
GO:0035098; ESC/E(Z) complex
Function: GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0003682; chromatin binding
GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0004407; histone deacetylase activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0031490; chromatin DNA binding
GO:0032041; NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558; protein deacetylase activity
GO:0043565; sequence-specific DNA binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
BRCA1, TOP2A, RELA, HDAC1, SP1, SIN3A, MXD1
STRING interaction network
Protein-Protein network diagram for HDAC2

Retrieve sequences for HDAC2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hda-1
Mus musculus
Hdac2
Rattus norvegicus
Hdac2
Schizosaccharomyces pombe
clr6

Selected references

External links

EPD
HS_HDAC2
ORF Accession
NM_001527
CDS Accession
NP_001518
OMIM
605164
HPRD
05521
Ensembl
HDAC2
UniProt/Swiss-Prot
HDAC2_HUMAN
GeneCards
HDAC2
Entrez Gene
3066
UniGene
3352
GenAtlas
HDAC2
Internet
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