GenAge entry for PTPN1 (Homo sapiens)

Gene name (HAGRID: 33)

HGNC symbol
PTPN1 
Aliases
PTP1B 
Common name
protein tyrosine phosphatase, non-receptor type 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PTPN1 inhibits insulin (INS) signalling and plays a role in INS sensitivity and fuel metabolism. Mice lacking PTPN1 are protected from diet-induced obesity and have enhanced enhanced INS sensitivity [323]. PTP1B negatively regulates leptin (LEP) signalling [1912]. PTPN1 may thus be related to certain age-associated pathologies such as obesity.

Cytogenetic information

Cytogenetic band
20q13.1-q1
Location
50,510,321 bp to 50,584,762 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006470; protein dephosphorylation
GO:0006987; activation of signaling protein activity involved in unfolded protein response
GO:0007257; activation of JUN kinase activity
GO:0008286; insulin receptor signaling pathway
GO:0009966; regulation of signal transduction
GO:0009968; negative regulation of signal transduction
GO:0030100; regulation of endocytosis
GO:0030948; negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968; endoplasmic reticulum unfolded protein response
GO:0031532; actin cytoskeleton reorganization
GO:0033157; regulation of intracellular protein transport
And 17 more GO terms
Cellular component: GO:0005769; early endosome
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0097443; sorting endosome
GO:0098554; cytoplasmic side of endoplasmic reticulum membrane
Function: GO:0004725; protein tyrosine phosphatase activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0030971; receptor tyrosine kinase binding
GO:0044822; poly(A) RNA binding
GO:0046875; ephrin receptor binding
GO:0051721; protein phosphatase 2A binding
GO:0098641; cadherin binding involved in cell-cell adhesion
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, IGF1R, STAT5B, STAT3, STAT5A, IRS1, EGFR, INSR, GSK3B, GRB2, ATF2, JAK2, CTNNB1, ZMPSTE24
STRING interaction network
Protein-Protein network diagram for PTPN1

Retrieve sequences for PTPN1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ptpn1
Mus musculus
Ptpn1
Rattus norvegicus
Ptpn1

Selected references

External links

EPD
ORF Accession
NM_002827
CDS Accession
NP_002818
OMIM
176885
HPRD
01477
Ensembl
PTPN1
UniProt/Swiss-Prot
PTN1_HUMAN
GeneCards
PTPN1
Entrez Gene
5770
UniGene
417549
GenAtlas
PTPN1
Internet
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