GenAge entry for CDK1 (Homo sapiens)

Gene name (HAGRID: 201)

HGNC symbol
CDK1 
Aliases
CDC28A; CDC2 
Common name
cyclin-dependent kinase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

An important regulator of the cell cycle, CDK1 also appears to be involved in apoptosis. Age-related alterations to CDK1 have been reported in rats [875], but there is no direct evidence linking CDK1 to human ageing.

Cytogenetic information

Cytogenetic band
10q21.1
Location
60,778,454 bp to 60,794,852 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086; G2/M transition of mitotic cell cycle
GO:0000187; activation of MAPK activity
GO:0000226; microtubule cytoskeleton organization
GO:0006260; DNA replication
GO:0006281; DNA repair
GO:0006461; protein complex assembly
GO:0006915; apoptotic process
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007067; mitotic nuclear division
And 43 more GO terms
Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005813; centrosome
GO:0005829; cytosol
GO:0005876; spindle microtubule
GO:0016020; membrane
GO:0030496; midbody
GO:0070062; extracellular exosome
And 2 more GO terms
Function: GO:0003682; chromatin binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004693; cyclin-dependent protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity
GO:0030332; cyclin binding
GO:0030544; Hsp70 protein binding
GO:0035173; histone kinase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, E2F1, EGFR, BRCA1, RPA1, BCL2, VCP, HSP90AA1, ABL1, UBE2I, EP300, PML, FEN1, RB1, FOXM1, UCHL1, SIRT1, SP1, HMGB1, CCNA2, LMNB1, CDK1, TFDP1, POLA1, PPP1CA, TP53BP1, CDKN1A, HTRA2, SQSTM1, CDK7
STRING interaction network
Protein-Protein network diagram for CDK1

Retrieve sequences for CDK1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cdk-1
Danio rerio
cdk1
Drosophila melanogaster
cdc2
Mus musculus
Cdk1
Rattus norvegicus
Cdk1
Saccharomyces cerevisiae
CDC28

In other databases

CellAge
  • This gene is present as CDK1

Selected references

External links

EPD
HS_CDC2
ORF Accession
NM_001786
CDS Accession
NP_001777
OMIM
116940
HPRD
00302
Ensembl
CDK1
UniProt/Swiss-Prot
CDC2_HUMAN
GeneCards
CDK1
Entrez Gene
983
UniGene
334562
GenAtlas
CDK1
Internet
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