GenAge entry for IGF1R (Homo sapiens)

Gene name (HAGRID: 15)

HGNC symbol
IGF1R 
Aliases
JTK13; CD221; IGFIR; MGC18216; IGFR 
Common name
insulin-like growth factor 1 receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

The receptor for IGF1, IGF1R, mediates the activation of the IGF1-stimulated signalling cascade. Evidence from model organisms, including results from flies [187] and roundworms [239], relates IGF1R homologues to ageing, most likely as part of the GH1/IGF1 axis. Mice (129/SvPas genetic background) heterozygous for IGF1R live 26% longer, though it is unclear whether they age slower. Null mutants are not viable [18]. In the B6 genetic background however, IGF-1R+/- female mutants show only an 11% lifespan extension, while males do not show any changes in median lifespan and have a slightly shorter maximum lifespan [3549]. In male mice where IGF1R has been knocked out specifically in cardiomyocytes, cardiac aging is attenuated. Fibrosis and expression of proinflammatory cytokines and NFKB1 are reduced when compared to wild type mice [4351].

The IGF1/GH1 axis appears to impact on ageing in model organisms, including rodents, and so IGF1R may affect human ageing. In humans, IGF1R has been implicated with growth retardation [186], and genotype combinations in the human IGF1R and PIK3CB genes have been related to plasma IGF1 levels and longevity [141].

Cytogenetic information

Cytogenetic band
15q26.3
Location
98,648,539 bp to 98,964,530 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006955; immune response
GO:0007165; signal transduction
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0030335; positive regulation of cell migration
GO:0038083; peptidyl-tyrosine autophosphorylation
GO:0043066; negative regulation of apoptotic process
GO:0045740; positive regulation of DNA replication
GO:0046328; regulation of JNK cascade
GO:0046777; protein autophosphorylation
And 5 more GO terms
Cellular component: GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0016020; membrane
GO:0035867; alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0043231; intracellular membrane-bounded organelle
GO:0043235; receptor complex
Function: GO:0004713; protein tyrosine kinase activity
GO:0005010; insulin-like growth factor-activated receptor activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0005524; ATP binding
GO:0031994; insulin-like growth factor I binding
GO:0042802; identical protein binding
GO:0043548; phosphatidylinositol 3-kinase binding
GO:0043559; insulin binding
GO:0043560; insulin receptor substrate binding
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, PTPN11, STAT3, IGF1, IRS1, PTPN1, EGFR, ERBB2, IGFBP3, HSP90AA1, APP, PTK2, PIK3R1, MDM2, ESR1, SOCS2
STRING interaction network
Protein-Protein network diagram for IGF1R

Retrieve sequences for IGF1R

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
igf1rb
Mus musculus
Igf1r
Rattus norvegicus
Igf1r

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Igf1r
LongevityMap
  • This gene is present as IGF1R

Selected references

External links

EPD
ORF Accession
NM_000875
CDS Accession
NP_000866
OMIM
147370
HPRD
00932
Ensembl
IGF1R
UniProt/Swiss-Prot
IGF1R_HUMAN
GeneCards
IGF1R
Entrez Gene
3480
UniGene
643120
GenAtlas
IGF1R
Internet
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