GenAge entry for MAP3K5 (Homo sapiens)

Gene name (HAGRID: 179)

HGNC symbol
MAP3K5 
Aliases
MAPKKK5; ASK1; MEKK5 
Common name
mitogen-activated protein kinase kinase kinase 5 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

MAP3K5, also called ASK1, is involved in stress response and apoptosis [999]. Disruption of MAP3K5 in mice attenuates left ventricular remodelling [1723]. It is possible that MAP3K5 is related to age-related changes in stress response witnessed in a number of animal models. MAP3K5 has not been directly linked to human ageing.

Cytogenetic information

Cytogenetic band
6q22.33
Location
136,557,049 bp to 136,792,518 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0002931; response to ischemia
GO:0006468; protein phosphorylation
GO:0007254; JNK cascade
GO:0007257; activation of JUN kinase activity
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010666; positive regulation of cardiac muscle cell apoptotic process
GO:0016032; viral process
GO:0034976; response to endoplasmic reticulum stress
GO:0038066; p38MAPK cascade
And 18 more GO terms
Cellular component: GO:0005829; cytosol
GO:0009897; external side of plasma membrane
GO:1902911; protein kinase complex
GO:1990604; IRE1-TRAF2-ASK1 complex
Function: GO:0000287; magnesium ion binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004709; MAP kinase kinase kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019901; protein kinase binding
GO:0019903; protein phosphatase binding
GO:0042803; protein homodimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TXN, PTPN11, AKT1, CREBBP, HSP90AA1, EP300, FAS, APP, HSPA1A, YWHAZ, MAP3K5, PIK3R1, JAK2, STUB1, CDKN1A
STRING interaction network
Protein-Protein network diagram for MAP3K5

Retrieve sequences for MAP3K5

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
map3k5
Drosophila melanogaster
Pk92B
Mus musculus
Map3k5
Rattus norvegicus
Map3k5

Selected references

External links

EPD
ORF Accession
NM_005923
CDS Accession
NP_005914
OMIM
602448
HPRD
03904
Ensembl
MAP3K5
UniProt/Swiss-Prot
M3K5_HUMAN
GeneCards
MAP3K5
Entrez Gene
4217
UniGene
186486
GenAtlas
MAP3K5
Internet
Search Google