| Description | A transcription factor of the Fox family, FOXO1 is important in development [0802]. It also appears to regulate apoptotic signals.
A homologue of FOXO1A, daf-16, has been associated with ageing in roundworms [0628], and overexpression of another homologue, dFOXO, in adult fat body of fruit flies increased longevity in females [1238]. Mice overexpressing FOXO1 in skeletal muscle weighed less than controls and had a reduced skeletal muscle mass, suggesting that FOXO1 could play a role in the age-related decline in muscle mass [1467]. Results from mice also suggest that FOXO1 could be involved in type 2 diabetes [0630]. Although at present there is no evidence directly linking FOXO1 to human ageing, it remains a putative player in the human ageing process. |
[1909] de Candia et al. (2008), A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathway, PubMed
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[1775] Baugh and Sternberg (2006), DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest, PubMed
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[1583] Greer and Brunet (2005), FOXO transcription factors at the interface between longevity and tumor suppression, PubMed
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[1334] Papaconstantinou et al. (2005), Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice, PubMed
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[1743] Altomonte et al. (2004), Foxo1 mediates insulin action on apoC-III and triglyceride metabolism, PubMed
[1107] Quarrie and Riabowol (2004), Murine models of life span extension, PubMed
[1467] Kamei et al. (2004), Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic control, PubMed
[1095] Daitoku et al. (2004), Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity, PubMed
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[0141] Bonafe et al. (2003), Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control, PubMed
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[0626] Hsu et al. (2003), Regulation of aging and age-related disease by DAF-16 and heat-shock factor, PubMed
[1469] Nakae et al. (2003), The forkhead transcription factor Foxo1 regulates adipocyte differentiation, PubMed
[0801] Furuyama et al. (2002), Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles, PubMed
[0630] Nakae et al. (2002), Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1, PubMed
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[0199] Tissenbaum and Guarente (2001), Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, PubMed
[1468] Anderson et al. (2001), Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3, PubMed
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[0958] Honda and Honda (1999), The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans, PubMed
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[0957] Lin et al. (1997), daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans, PubMed
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