GenAge entry for EPOR (Homo sapiens)

Gene name (HAGRID: 52)

HGNC symbol
EPOR 
Aliases
EPO-R 
Common name
Erythropoietin receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Cytogenetic information

Cytogenetic band
19p13.2
Location
11,377,204 bp to 11,384,341 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007165; signal transduction
GO:0007420; brain development
GO:0007507; heart development
GO:0046697; decidualization
Cellular component: GO:0005576; extracellular region
GO:0005887; integral component of plasma membrane
Function: GO:0004900; erythropoietin receptor activity
GO:0042802; identical protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, PTPN11, STAT5A, IRS2, GRB2, PIK3R1, JAK2, SOCS2
STRING interaction network
Protein-Protein network diagram for EPOR

Retrieve sequences for EPOR

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
epor
Mus musculus
Epor
Rattus norvegicus
Epor

Selected references

External links

EPD
ORF Accession
NM_000121
CDS Accession
NP_000112
OMIM
133171
HPRD
Ensembl
EPOR
UniProt/Swiss-Prot
EPOR_HUMAN
GeneCards
EPOR
Entrez Gene
2057
UniGene
631624
GenAtlas
EPOR
Internet
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