GenAge entry for IL2RG (Homo sapiens)

Gene name (HAGRID: 49)

HGNC symbol
IL2RG 
Aliases
CD132; SCIDX1; IMD4; CIDX 
Common name
interleukin 2 receptor, gamma 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

A crucial component in IL2 signal transduction, IL2RG could be related to the age-associated functional decline in the immune system [369].

Cytogenetic information

Cytogenetic band
Xq13.1
Location
71,107,406 bp to 71,111,631 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006955; immune response
GO:0007165; signal transduction
GO:0019048; modulation by virus of host morphology or physiology
GO:0035771; interleukin-4-mediated signaling pathway
GO:0038110; interleukin-2-mediated signaling pathway
GO:0038111; interleukin-7-mediated signaling pathway
Cellular component: GO:0005886; plasma membrane
GO:0005887; integral to plasma membrane
GO:0009897; external side of plasma membrane
Function: GO:0004911; interleukin-2 receptor activity
GO:0004913; interleukin-4 receptor activity
GO:0004917; interleukin-7 receptor activity
GO:0005515; protein binding
GO:0019976; interleukin-2 binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, STAT5A, IL2, IL7
STRING interaction network
Protein-Protein network diagram for IL2RG

Retrieve sequences for IL2RG

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
il2rgb
Mus musculus
Il2rg
Rattus norvegicus
Il2rg

Selected references

External links

EPD
HS_IL2RG
ORF Accession
NM_000206
CDS Accession
NP_000197
OMIM
308380
HPRD
02391
Ensembl
IL2RG
UniProt/Swiss-Prot
IL2RG_HUMAN
GeneCards
IL2RG
Entrez Gene
3561
UniGene
84
GenAtlas
IL2RG
Internet
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