GenAge entry for PRKCA (Homo sapiens)

Gene name (HAGRID: 99)

HGNC symbol
PRKCA 
Aliases
PKCA 
Common name
protein kinase C, alpha 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PRKCA is a phorbol ester receptor involved in signal transduction. It appears to interact with many proteins, including some that have been related to ageing, such as LMNA and INSR. In the medfly, PRKCA levels are age-dependent [535]. PRKCA has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
17q22-q23.
Location
66,302,808 bp to 66,810,744 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000188; inactivation of MAPK activity
GO:0001525; angiogenesis
GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002026; regulation of the force of heart contraction
GO:0002062; chondrocyte differentiation
GO:0002159; desmosome assembly
GO:0006112; energy reserve metabolic process
GO:0006468; protein phosphorylation
GO:0006874; cellular calcium ion homeostasis
GO:0006937; regulation of muscle contraction
And 46 more GO terms
Cellular component: GO:0001750; photoreceptor outer segment
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0030425; dendrite
GO:0031966; mitochondrial membrane
GO:0043025; neuronal cell body
GO:0048471; perinuclear region of cytoplasm
Function: GO:0004672; protein kinase activity
GO:0004697; protein kinase C activity
GO:0004698; calcium-dependent protein kinase C activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008270; zinc ion binding
GO:0019899; enzyme binding
GO:0035403; histone kinase activity (H3-T6 specific)
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERT, LMNA, EGFR, INSR, BCL2, YWHAZ, PTK2B, HMGB1, LMNB1, CDC42, ADCY5, RICTOR
STRING interaction network
Protein-Protein network diagram for PRKCA

Retrieve sequences for PRKCA

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
prkca
Mus musculus
Prkca
Rattus norvegicus
Prkca

In other databases

LongevityMap
  • This gene is present as PRKCA

Selected references

External links

EPD
ORF Accession
NM_002737
CDS Accession
NP_002728
OMIM
176960
HPRD
01498
Ensembl
PRKCA
UniProt/Swiss-Prot
KPCA_HUMAN
GeneCards
PRKCA
Entrez Gene
5578
UniGene
531704
GenAtlas
PRKCA
Internet
Search Google