GenAge entry for BAX (Homo sapiens)

Gene name (HAGRID: 119)

HGNC symbol
BAX 
Aliases
BCL2L4 
Common name
BCL2-associated X protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

An important player in apoptosis, BAX encodes multiple transcripts and has been linked to development, cancer, and age-related changes in apoptosis [600]. Inactivation of BAX in mice extended fertile potential and minimized age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. It did not extend lifespan [1927]. Changes in apoptotic proteins like BAX could also contribute to ageing-associated atrophy in the skeletal muscle of rats [1639]. It is not known how these processes are related to human ageing, but a role of BAX in human ageing is a possibility.

Cytogenetic information

Cytogenetic band
19q13.3-q1
Location
48,954,860 bp to 48,961,262 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001101; response to acid
GO:0001541; ovarian follicle development
GO:0001764; neuron migration
GO:0001777; T cell homeostatic proliferation
GO:0001782; B cell homeostasis
GO:0001783; B cell apoptotic process
GO:0001822; kidney development
GO:0001836; release of cytochrome c from mitochondria
GO:0001844; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974; blood vessel remodeling
GO:0002262; myeloid cell homeostasis
And 70 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005741; mitochondrial outer membrane
GO:0005757; mitochondrial permeability transition pore complex
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0046930; pore complex
GO:0097136; Bcl-2 family protein complex
Function: GO:0005515; protein binding
GO:0008289; lipid binding
GO:0015267; channel activity
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0046982; protein heterodimerization activity
GO:0051434; BH3 domain binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
BCL2, KCNA3, BAK1
STRING interaction network
Protein-Protein network diagram for BAX

Retrieve sequences for BAX

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
baxa
Mus musculus
Bax
Rattus norvegicus
Bax

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Bax
LongevityMap
  • This gene is present as BAX

Selected references

External links

EPD
ORF Accession
NM_004324
CDS Accession
NP_004315
OMIM
600040
HPRD
02498
Ensembl
BAX
UniProt/Swiss-Prot
BAX_HUMAN
GeneCards
BAX
Entrez Gene
581
UniGene
631546
GenAtlas
BAX
Internet
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