GenAge entry for BRCA2 (Homo sapiens)

Gene name (HAGRID: 0079)

Potential relevance to the human ageing process

Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing

BRCA2 is an important protein in cellular responses to DNA damage and may be directly involved in DNA repair. Mice deficient for BRCA2 have a reduced lifespan, though it is not clear whether they age faster [0475]. Although BRCA2's role in cancer is clear [1676], elucidating its role in human ageing will require additional studies.

Cytogenetic information

Display region using the UCSC Genome Browser

Protein information

GO:0000724; double-strand break repair via homologous recombination; Process
GO:0001556; oocyte maturation; Process
GO:0001833; inner cell mass cell proliferation; Process
GO:0006310; DNA recombination; Process
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; Process
GO:0007141; male meiosis I; Process
GO:0007283; spermatogenesis; Process
GO:0007420; brain development; Process
GO:0007569; cell aging; Process
GO:0007584; response to nutrient; Process
GO:0008585; female gonad development; Process
GO:0010165; response to X-ray; Process
GO:0010225; response to UV-C; Process
GO:0010332; response to gamma radiation; Process
GO:0030879; mammary gland development; Process
GO:0035264; multicellular organism growth; Process
GO:0042771; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; Process
GO:0043009; chordate embryonic development; Process
GO:0045931; positive regulation of mitotic cell cycle; Process
GO:0048478; replication fork protection; Process

GO:0003697; single-stranded DNA binding; Function

GO:0005737; cytoplasm; Cellular component

Protein-protein interactions

Display interactions using the IGD

Retrieve sequences for BRCA2

Homologues in model organisms

HomoloGene (41)

Selected references

[0475] Donoho et al. (2003), Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice, PubMed
[0489] Pellegrini et al. (2002), Insights into DNA recombination from the structure of a RAD51-BRCA2 complex, PubMed
[1679] Brown and Baltimore (2000), ATR disruption leads to chromosomal fragmentation and early embryonic lethality, PubMed
[0476] Lee et al. (1999), Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2, PubMed
[0396] Fearon (1997), Human cancer syndromes: clues to the origin and nature of cancer, PubMed
[0478] Suzuki et al. (1997), Brca2 is required for embryonic cellular proliferation in the mouse, PubMed
[0477] Ludwig et al. (1997), Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos, PubMed
[1676] Wooster et al. (1995), Identification of the breast cancer susceptibility gene BRCA2, PubMed

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External links