GenAge entry for EGF (Homo sapiens)

Gene name (HAGRID: 48)

HGNC symbol
EGF 
Aliases
 
Common name
epidermal growth factor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

EGF stimulates the growth of several epidermal and epithelial cell types. It is also involved in differentiation [366]. Expression of EGF in transgenic mice causes stunted growth [367]. An attenuation of EGF signalling has been reported with age [346], but it is unclear whether these are causes or effects of ageing.

Cytogenetic information

Cytogenetic band
4q25
Location
109,912,884 bp to 110,012,962 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000186; activation of MAPKK activity
GO:0001525; angiogenesis
GO:0002576; platelet degranulation
GO:0006260; DNA replication
GO:0007165; signal transduction
GO:0007171; activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007262; STAT protein import into nucleus
GO:0007596; blood coagulation
GO:0008284; positive regulation of cell proliferation
GO:0008543; fibroblast growth factor receptor signaling pathway
And 26 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005765; lysosomal membrane
GO:0005886; plasma membrane
GO:0016021; integral to membrane
GO:0031093; platelet alpha granule lumen
Function: GO:0005154; epidermal growth factor receptor binding
GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0030297; transmembrane receptor protein tyrosine kinase activator activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
STAT3, NRG1, EGFR, ERBB2, CEBPB, GRB2
STRING interaction network
Protein-Protein network diagram for EGF

Retrieve sequences for EGF

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
egf
Mus musculus
Egf
Rattus norvegicus
uncharacterized_M0RA

In other databases

LongevityMap
  • This gene is present as EGF

Selected references

External links

EPD
ORF Accession
NM_001963
CDS Accession
NP_001954
OMIM
131530
HPRD
00578
Ensembl
EGF
UniProt/Swiss-Prot
EGF_HUMAN
GeneCards
EGF
Entrez Gene
1950
UniGene
419815
GenAtlas
EGF
Internet
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