GenAge entry for PIK3CA (Homo sapiens)

Gene name (HAGRID: 286)

HGNC symbol
PIK3CA 
Aliases
PI3K 
Common name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

PIK3CA plays a role in activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. MTOR is a downstream effector of phosphoinositide 3-kinase, and thus PIK3CA might be also involved in ageing.

In mice, suppression of the activity of the p110alpha isoform of PIK3CA preserved cardiac function and prevented many age-associated changes in the heart [2227]. PIK3CA is also an oncogene and has been implicated in several types of cancers.

Cytogenetic information

Cytogenetic band
3q26.3
Location
179,148,523 bp to 179,234,709 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001525; angiogenesis
GO:0001889; liver development
GO:0001944; vasculature development
GO:0006006; glucose metabolic process
GO:0006468; protein phosphorylation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0010468; regulation of gene expression
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0016310; phosphorylation
GO:0030168; platelet activation
And 27 more GO terms
Cellular component: GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005942; phosphatidylinositol 3-kinase complex
GO:0005943; phosphatidylinositol 3-kinase complex, class IA
GO:0030027; lamellipodium
Function: GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0030295; protein kinase activator activity
GO:0035004; phosphatidylinositol 3-kinase activity
GO:0035005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560; insulin receptor substrate binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IRS1, IRS2, AKT1, HRAS, GRB2, HDAC1, PIK3R1, ESR1, ATR, SQSTM1
STRING interaction network
Protein-Protein network diagram for PIK3CA

Retrieve sequences for PIK3CA

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
LOC100334726
Mus musculus
Pik3ca
Rattus norvegicus
Pik3ca

In other databases

LongevityMap
  • This gene is present as PIK3CA

Selected references

External links

EPD
ORF Accession
NM_006218
CDS Accession
NP_006209
OMIM
171834
HPRD
01382
Ensembl
PIK3CA
UniProt/Swiss-Prot
PK3CA_HUMAN
GeneCards
PIK3CA
Entrez Gene
5290
UniGene
553498
GenAtlas
PIK3CA
Internet
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