GenAge entry for YWHAZ (Homo sapiens)

Gene name (HAGRID: 164)

HGNC symbol
YWHAZ 
Aliases
KCIP-1; 14-3-3-zeta; YWHAD 
Common name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

YWHAZ is an adapter protein implicated in several signal transduction pathways [997]. Although YWHAZ has not been directly related to ageing, because it interacts with so many proteins, including many associated with ageing such as the INS/IGF1 pathway [996], it is possible that YWHAZ itself plays some role in human ageing.

Cytogenetic information

Cytogenetic band
8q23.1
Location
100,918,576 bp to 100,952,129 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007165; signal transduction
GO:0030168; platelet activation
GO:0043066; negative regulation of apoptotic process
GO:0043488; regulation of mRNA stability
GO:0051683; establishment of Golgi localization
GO:0061024; membrane organization
GO:0090168; Golgi reassembly
GO:0098609; cell-cell adhesion
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0005925; focal adhesion
GO:0030659; cytoplasmic vesicle membrane
GO:0042470; melanosome
GO:0070062; extracellular exosome
And 2 more GO terms
Function: GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019901; protein kinase binding
GO:0019904; protein domain specific binding
GO:0031625; ubiquitin protein ligase binding
GO:0042802; identical protein binding
GO:0044822; poly(A) RNA binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERT, IRS2, AKT1, EGFR, NCOR1, PRKCD, BRCA1, VCP, ABL1, EP300, PRKCA, XRCC6, GRB2, FOXO3, FOXO1, APP, RAD52, HSPA1B, MAPK8, YWHAZ, MAP3K5, MAPT, H2AFX, MTOR, CTNNB1, UCP3, UCP2, TP53BP1, SQSTM1
STRING interaction network
Protein-Protein network diagram for YWHAZ

Retrieve sequences for YWHAZ

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Ywhaz
Rattus norvegicus
Ywhaz

Selected references

External links

EPD
ORF Accession
NM_145690
CDS Accession
NP_663723
OMIM
601288
HPRD
03183
Ensembl
YWHAZ
UniProt/Swiss-Prot
1433Z_HUMAN
GeneCards
YWHAZ
Entrez Gene
7534
UniGene
492407
GenAtlas
YWHAZ
Internet
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