GenAge entry for MTOR (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 221)

HGNC symbol
MTOR 
Aliases
RAFT1; RAPT1; FLJ44809; FRAP; FRAP2; FRAP1 
Common name
mechanistic target of rapamycin (serine/threonine kinase) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

The MTOR kinase belongs to the target of rapamycin group of enzymes which regulate cellular growth and proliferation [1318].

TOR enzymes, homologues of MTOR, have been linked to ageing in lower organisms. In yeast, deletions in the nutrient-responsive TOR pathway increased lifespan, and caloric restriction failed to further increase lifespan [1570]. Similarly, in roundworms, TOR deficiency more than doubled the lifespan [1319], and TOR disruption in fruit flies also extended lifespan [1317]. In invertebrates, a functional link between MTOR and insulin (INS)/IGF1 signalling has been proposed [1322], which further hints of a role for MTOR in ageing. Mice hypomorphic for mTor have reduced mTor expression, are smaller and live 20% longer [3258]. Female mice heterozygous for both mTOR and mLST8 also exhibit decreased mTORC1 activity and extended life span but have normal glucose tolerance and insulin sensitivity. While rapamycin also disrupts the mTORC2 complex, the lifespan extension is mediated through the mTORC1 complex [3628]. More work is needed to determine whether MTOR is associated with human ageing but it is a promising target for further research.

Cytogenetic information

Cytogenetic band
1p36.2
Location
11,106,531 bp to 11,262,551 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0005979; regulation of glycogen biosynthetic process
GO:0006468; protein phosphorylation
GO:0006950; response to stress
GO:0007165; signal transduction
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007281; germ cell development
GO:0007584; response to nutrient
GO:0008286; insulin receptor signaling pathway
GO:0008543; fibroblast growth factor receptor signaling pathway
And 38 more GO terms
Cellular component: GO:0000139; Golgi membrane
GO:0005737; cytoplasm
GO:0005741; mitochondrial outer membrane
GO:0005764; lysosome
GO:0005765; lysosomal membrane
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0005942; phosphatidylinositol 3-kinase complex
GO:0012505; endomembrane system
GO:0016020; membrane
GO:0016605; PML body
And 4 more GO terms
Function: GO:0001030; RNA polymerase III type 1 promoter DNA binding
GO:0001031; RNA polymerase III type 2 promoter DNA binding
GO:0001032; RNA polymerase III type 3 promoter DNA binding
GO:0001156; TFIIIC-class transcription factor binding
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008144; drug binding
GO:0016301; kinase activity
GO:0019904; protein domain specific binding
GO:0043022; ribosome binding
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
RICTOR
STRING interaction network
Protein-Protein network diagram for MTOR

Retrieve sequences for MTOR

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
let-363
Drosophila melanogaster
Tor
Danio rerio
mtor
Mus musculus
Mtor
Rattus norvegicus
Mtor
Saccharomyces cerevisiae
TOR2
Schizosaccharomyces pombe
tor2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as let-363
  • A homolog of this gene for Drosophila melanogaster is present as Tor
  • A homolog of this gene for Mus musculus is present as Mtor
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as let-363
LongevityMap
  • This gene is present as MTOR

Selected references

External links

EPD
ORF Accession
NM_004958
CDS Accession
NP_004949
OMIM
601231
HPRD
03134
Ensembl
MTOR
UniProt/Swiss-Prot
FRAP_HUMAN
GeneCards
MTOR
Entrez Gene
2475
UniGene
338207
GenAtlas
MTOR
Internet
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