GenAge entry for CISD2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 265)

HGNC symbol
CISD2 
Aliases
Miner1; ERIS; NAF-1; ZCD2; WFS2 
Common name
CDGSH iron sulfur domain 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

Knockout mice for CISD2, the causative gene in Wolfram syndrome 2, show an increased mitochondrial breakdown and dysfunction accompanied by autophagic cell death. Mice exhibit multiple signs of premature aging: prominent eyes and protruding ears, ocular abnormalities, early depigmentation of the fur, hair follicle atrophy, decreased hair density and regrowth rate, thickened dermis, significant decrease in subcutaneous adipose tissue and muscle, muscle atrophy, osteroporosis, decrease in pulmonary capacity, and have a shorter lifespan [2153]. In wild type, the expression levels of CISD2 decrease with age [2154]. Transgenic expression in mice extend lifespan [3315]. As such, CISD2 is a strong candidate for a role in ageing, though further human studies are warranted.

Cytogenetic information

Cytogenetic band
4q24
Location
102,868,978 bp to 102,892,806 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000422; mitochondrion degradation
GO:0010259; multicellular organismal aging
GO:0010506; regulation of autophagy
Cellular component: GO:0005741; mitochondrial outer membrane
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0016021; integral to membrane
GO:0043234; protein complex
Function: GO:0005515; protein binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0051537; 2 iron, 2 sulfur cluster binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for CISD2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
CELE_W02B12.15
Drosophila melanogaster
CG1458
Danio rerio
cisd2
Mus musculus
Cisd2
Rattus norvegicus
Cisd2

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Cisd2

Selected references

External links

EPD
ORF Accession
NM_001008388
CDS Accession
NP_001008389
OMIM
611507
HPRD
17413
Ensembl
CISD2
UniProt/Swiss-Prot
CISD2_HUMAN
GeneCards
CISD2
Entrez Gene
493856
UniGene
444955
GenAtlas
CISD2
Internet
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