GenAge entry for HMGB2 (Homo sapiens)

Gene name (HAGRID: 178)

HGNC symbol
HMGB2 
Aliases
HMG2 
Common name
high mobility group box 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

HMGB2 has been related to DNA unwinding and stress response. In mice, HMGB2 and other HMG chromosomal proteins have been shown to suffer alterations at various levels during ageing [790], though HMGB2 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
4q31
Location
173,331,376 bp to 173,334,444 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001938; positive regulation of endothelial cell proliferation
GO:0002437; inflammatory response to antigenic stimulus
GO:0006265; DNA topological change
GO:0006309; apoptotic DNA fragmentation
GO:0006325; chromatin organization
GO:0006334; nucleosome assembly
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0007289; spermatid nucleus differentiation
GO:0008584; male gonad development
GO:0032075; positive regulation of nuclease activity
And 24 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0000793; condensed chromosome
GO:0005615; extracellular space
GO:0005623; cell
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0043234; protein complex
GO:0048471; perinuclear region of cytoplasm
Function: GO:0000400; four-way junction DNA binding
GO:0001158; enhancer sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008144; drug binding
GO:0008301; DNA binding, bending
And 8 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CREBBP, NR3C1, AR, APP, HMGB1
STRING interaction network
Protein-Protein network diagram for HMGB2

Retrieve sequences for HMGB2

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
hmgb2a
Mus musculus
Hmgb2
Rattus norvegicus
Hmgb2

Selected references

External links

EPD
HS_HMGB2
ORF Accession
NM_002129
CDS Accession
NP_002120
OMIM
163906
HPRD
01229
Ensembl
HMGB2
UniProt/Swiss-Prot
HMGB2_HUMAN
GeneCards
HMGB2
Entrez Gene
3148
UniGene
434953
GenAtlas
HMGB2
Internet
Search Google